RGD Reference Report - Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat. - Rat Genome Database

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Changes in mRNA expression of ABC and SLC transporters in liver and intestines of the adjuvant-induced arthritis rat.

Authors: Uno, S  Uraki, M  Ito, A  Shinozaki, Y  Yamada, A  Kawase, A  Iwaki, M 
Citation: Uno S, etal., Biopharm Drug Dispos. 2009 Jan;30(1):49-54.
RGD ID: 2315573
Pubmed: PMID:19152228   (View Abstract at PubMed)
DOI: DOI:10.1002/bdd.639   (Journal Full-text)

In this study, a real-time reverse transcription-polymerase chain reaction was used to determine the effects of adjuvant-induced arthritis (AA) on the amounts of mRNA of 12 types of rat ATP-binding cassette (ABC) and solute carrier (SLC) transporters in the liver and small intestine, 7 (D7) and 21 days (D21) after the injection of adjuvant. There were no significant differences in mRNA levels of ABC and SLC transporters between the livers of AA and control rats on D7, except in the case of Mdr1a. However, levels of Mdr1a, Mrp2 and Oatp SLC transporters were significantly lower in AA than in the control livers on D21. In contrast, the mRNA levels of several ABC and SLC transporters, especially Mrp2, Bcrp, LAT2 and Oatp1a5, were significantly lower in the small intestines of AA rats compared with the controls on D7, though there were no significant differences by D21. The time-dependent alterations in mRNA levels of the pregnane X receptor, but not the constitutive androstane receptor, in the liver and intestine were similar to the changes in mRNA levels of most transporters examined. The present study showed that AA was associated with reduced mRNA expression of several ABC and SLC transporters in the liver and small intestine, but that the time courses of the effects of AA on mRNA expression differed between the liver and small intestine. These results raise the possibility of a functional change of the transporters of liver and intestine in AA rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Arthritis  ISOAbcb1a (Rattus norvegicus)2315573; 2315573mRNA:altered expression:liverRGD 
Experimental Arthritis  ISOAbcg2 (Rattus norvegicus)2315573; 2315573mRNA:decreased expression:small intestineRGD 
Experimental Arthritis  IEP 2315573mRNA:altered expression:liverRGD 
Experimental Arthritis  IEP 2315573mRNA:decreased expression:small intestineRGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)
Abcg2  (ATP binding cassette subfamily G member 2)

Genes (Mus musculus)
Abcb1a  (ATP-binding cassette, sub-family B member 1A)
Abcg2  (ATP binding cassette subfamily G member 2 (Junior blood group))

Genes (Homo sapiens)
ABCB1  (ATP binding cassette subfamily B member 1)
ABCG2  (ATP binding cassette subfamily G member 2 (JR blood group))


Additional Information