Abcb1a<sup>em2Sage</sup> (ATP binding cassette subfamily B member 1A; ZFN induced mutant 2, Sage) - Rat Genome Database

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Gene: Abcb1aem2Sage (ATP binding cassette subfamily B member 1A; ZFN induced mutant 2, Sage) Rattus norvegicus
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Symbol: Abcb1aem2Sage
Name: ATP binding cassette subfamily B member 1A; ZFN induced mutant 2, Sage
RGD ID: 12907569
Description: The ZFN-induced mutant allele contains 19-bp deletion in exon7 resulting total loss of protein expression.
ASSOCIATED WITH abnormal blood-brain barrier function; abnormal intestinal absorption
Type: allele  of Abcb1a  
Previously known as: Abcb1a^[em2Sage]; Abcb1aem2Sage
Is Marker For: Strains:   WI-Abcb1aem2Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Characterization of multidrug resistance 1a/P-glycoprotein knockout rats generated by zinc finger nucleases. Chu X, etal., Mol Pharmacol. 2012 Feb;81(2):220-7. doi: 10.1124/mol.111.074179. Epub 2011 Nov 2.

Genomics

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Abcb1aem2Sage-var1 chr4 25413964 25413982 GAACAGGGCTGATGGCCAA - deletion mRatBN7.2
Abcb1aem2Sage-var1 chr4 22396614 22396632 GAACAGGGCTGATGGCCAA - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Abcb1aem2Sage


Expression


Sequence

Nucleotide Sequences


Additional Information