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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:9768
Term: Tryptanthrine
Definition: An alkaloid antibiotic that has formula C15H8N2O2.
Chemical ID: MESH:C046243
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aaffects bindingISOABCB1 (Homo sapiens)6480464CTDtryptanthrine binds to ABCB1 promoterPMID:17482571
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDtryptanthrine results in decreased expression of ABCB1 mRNA; tryptanthrine results in decreased expression of ABCB1 proteinPMID:17482571
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