GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | increases expression | EXP | | 6480464 | CTD | Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA | PMID:19162173 | Abcb1a | increases expression | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA; Pregnenolone Carbonitrile results in increased expression of ABCB1 protein; Pregnenolone Carbonitrile results in increased expression of ABCB1A mRNA | PMID:15456840 PMID:16819505 PMID:29863087 | Abcb1a | multiple interactions | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 mRNA]; NR1I2 gene mutant form inhibits the reaction [Pregnenolone Carbonitrile results in increased expression of ABCB1 protein] | PMID:16819505 | | ||||||||||||||||||||||
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