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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:50399
Term: 3',4',7-trihydroxyisoflavone
Definition: A 7-hydroxyisoflavone that is daidzein substituted by a hydroxy group at position 3'.
Chemical ID: MESH:C061213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTD3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNAPMID:22914566
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Ascorbic Acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; CAT protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]PMID:22914566
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