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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTD2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1A mRNAPMID:11170838 PMID:17669244 PMID:21784091 PMID:22213190
Abcb1amultiple interactionsEXP 6480464CTDlipopolysaccharide, E coli O55-B5 inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1A mRNA]PMID:11170838
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTD2-Acetylaminofluorene results in decreased expression of ABCB1 mRNAPMID:12387747
Abcb1aincreases activityISOABCB1 (Homo sapiens)6480464CTD2-Acetylaminofluorene results in increased activity of ABCB1 proteinPMID:11960367
Abcb1aincreases expressionISOAbcb1a (Mus musculus)6480464CTD2-Acetylaminofluorene results in increased expression of ABCB1 mRNA; 2-Acetylaminofluorene results in increased expression of ABCB1 proteinPMID:17303067
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTD2-Acetylaminofluorene results in increased expression of ABCB1 mRNAPMID:11960367
Abcb1amultiple interactionsISOAbcb1a (Mus musculus)6480464CTDPhycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]; Phycocyanin inhibits the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 protein]PMID:17303067
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[2-Acetylaminofluorene results in increased activity of AKT1 protein] which results in increased expression of ABCB1 mRNA; [2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNA; [RELA protein binds to NFKB1 protein] affects the reaction [2-Acetylaminofluorene results in increased expression of ABCB1 mRNA]PMID:11960367
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