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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1aincreases expressionEXP 6480464CTDEmodin results in increased expression of ABCB1A mRNAPMID:19549930
Abcb1amultiple interactionsEXP 6480464CTDABCB1A protein promotes the reaction [Emodin results in increased export of calcein AM]PMID:19549930
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTDEmodin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]PMID:24380838
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