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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of ABCB1 mRNA; Dexamethasone results in decreased expression of ABCB1A mRNAPMID:17324141 PMID:20607812
Abcb1aincreases expressionEXP 6480464CTDDexamethasone results in increased expression of ABCB1 protein; Dexamethasone results in increased expression of ABCB1A mRNA; Dexamethasone results in increased expression of ABCB1A proteinPMID:17015168 PMID:19958760
Abcb1amultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of ABCB1A mRNA]PMID:15205389
Abcb1aaffects response to substanceISOABCB1 (Homo sapiens)6480464CTDABCB1 gene polymorphism affects the susceptibility to DexamethasonePMID:16321374
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDDexamethasone results in decreased activity of ABCB1 proteinPMID:12387747
Abcb1aincreases expressionISOABCB1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of ABCB1 mRNAPMID:12387747
Abcb1aincreases secretionISOABCB1 (Homo sapiens)6480464CTDABCB1 protein results in increased secretion of DexamethasonePMID:22464980
Abcb1amultiple interactionsISOABCB1 (Homo sapiens)6480464CTD[Tacrolimus results in decreased activity of ABCB1 protein] which results in decreased export of Dexamethasone; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IFNG protein]; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IL2 protein]; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IL4 protein]; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of TNF protein]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Dexamethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Dexamethasone]PMID:16321374 PMID:20080907 PMID:22464980
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