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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619951
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1a
Name: ATP binding cassette subfamily B member 1A
Acc ID: CHEBI:9513
Term: thalidomide
Definition: A racemate comprising equimolar amounts of R- and S-thalidomide.
Chemical ID: MESH:D013792
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1adecreases activityISOABCB1 (Homo sapiens)6480464CTDThalidomide results in decreased activity of ABCB1 proteinPMID:19840843
Abcb1adecreases expressionISOABCB1 (Homo sapiens)6480464CTDThalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 proteinPMID:15920492 PMID:19840843
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