RGD Reference Report - Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters. - Rat Genome Database

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Screening for impact of popular herbs improving mental abilities on the transcriptional level of brain transporters.

Authors: Mrozikiewicz, PM  Bogacz, A  Bartkowiak-Wieczorek, J  Kujawski, R  Mikolajczak, PL  Ozarowski, M  Czerny, B  Mrozikiewicz-Rakowska, B  Grzeskowiak, E 
Citation: Mrozikiewicz PM, etal., Acta Pharm. 2014 Jun;64(2):223-32. doi: 10.2478/acph-2014-0020.
RGD ID: 11041146
Pubmed: PMID:24914722   (View Abstract at PubMed)
DOI: DOI:10.2478/acph-2014-0020   (Journal Full-text)

There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB). The aim of this study was to investigate the effect of natural and synthetic substances on the expression level of genes encoding transporters present in the BBB (mdr1a, mdr1b, mrp1, mrp2, oatp1a4, oatp1a5 and oatp1c1). Our results showed that verapamil caused the greatest reduction in the mRNA level while other synthetic (piracetam, phenobarbital) and natural (codeine, cyclosporine A, quercetin) substances showed a selective inhibitory effect. Further, the extract from the roots of Panax ginseng C. A. Meyer exhibited a decrease of transcription against selected transporters whereas the extract from Ginkgo biloba L. leaves resulted in an increase of the expression level of tested genes, except for mrp2. Extract from the aerial parts of Hypericum perforatum L. was the only one to cause an increased mRNA level for mdr1 and oatp1c1. These findings suggest that herbs can play an important role in overcoming the BBB and multidrug resistance to pharmacotherapy of brain cancer and mental disorders, based on the activity of selected drug-metabolizing enzymes and transporters located in the BBB.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to codeine  IEP 11041146 RGD 
response to cyclosporin A  IEP 11041146 RGD 
response to quercetin  IEP 11041146 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Abcb1a  (ATP binding cassette subfamily B member 1A)


Additional Information