GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb1a | increases expression | EXP | | 6480464 | CTD | Genistein results in increased expression of ABCB1A mRNA | PMID:32185415 | Abcb1a | multiple interactions | EXP | | 6480464 | CTD | Ketoconazole inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA]; NR1I2 protein affects the reaction [Genistein results in increased expression of ABCB1A mRNA]; sulforaphane inhibits the reaction [Genistein results in increased expression of ABCB1A mRNA] | PMID:32185415 | Abcb1a | decreases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Genistein results in decreased expression of ABCB1 protein | PMID:34217736 | Abcb1a | increases activity | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Genistein results in increased activity of ABCB1 protein | PMID:34217736 | Abcb1a | increases expression | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Genistein results in increased expression of ABCB1 mRNA; Genistein results in increased expression of ABCB1 protein | PMID:18634814 PMID:24685904 | Abcb1a | multiple interactions | ISO | ABCB1 (Homo sapiens) | 6480464 | CTD | Fulvestrant inhibits the reaction [Genistein results in increased expression of ABCB1 protein]; Genistein promotes the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; Genistein promotes the reaction [Quercetin results in increased activity of ABCB1 protein]; Genistein results in increased expression of and results in increased activity of ABCB1 protein | PMID:24685904 PMID:34217736 | |
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