Gene:	Jun ( Rattus norvegicus ) Jun oncogene
Description:	transcription factor; acts as a protooncogene
Synonyms:	Avian sarcoma virus 17 (v-jun) oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian);  (details...)
ArrayIDs:	6027652; rc_AI175959_at; rc_AA944014_at; X17163cds_s_at; 6155367; rc_AA945867_at; 1374404_at; 6285488; 6685920; 1389528_s_at; 5788393; 5970154; 6485592; 6725675; 1369788_s_at; 5762249; 6534960; 6528597;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Ciaa5 - CIA Autoantibody QTL 5
Markers:	D5Lev15 D5Mgh23
Homologs
Homo sapiens: JUN     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Jun     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Jun genome assembly 3.1 5 115363396 - 115365980     Rat Celera Assembly 5 108510040 - 108513133     RGSC genome assembly v3.4 5 115358166 - 115361259     Cytogenetic 5 q34.1 Mus musculus Jun Mouse genome assembly build 36.1 4 94715746 - 94718878     Cytogenetic 4 4 C5-C7 Homo sapiens JUN human genome assembly 1 58958483 - 58961806     Human genome assembly build 36.2 1 59019051 - 59022373     Cytogenetic 1 p32-p31   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Other Map Data:	Associated SSLP Map Locations No mapping information currently available in RGD for D5Lev15 STS D5Mgh23 genome assembly 3.1 5 115367025 - 115367153     RH 3.4 5 779.4     Rat cytogenetic map 5     RGSC genome assembly v3.4 5 115361799 - 115361927     RH 2.0 5 702.5
Annotation
Molecular Function	Note Reference transcription factor 628503 Gene Ontology RNA polymerase II transcription factor activity,  transcription factor activity,  protein homodimerization activity ...  (details...)
Biological Process	Note Reference mediates cellular proliferation 628503 Gene Ontology response to cytokine stimulus,  response to cAMP,  regulation of transcription, DNA-dependent ...  (details...)
Cellular Component	Gene Ontology transcription factor complex,  nucleus,  nuclear chromatin ...  (details...)
Disease	Ontology Osteopetrosis,  Kidney Neoplasms,  Carcinoma, Renal Cell ...  (details...)
Phenotype	Ontology abnormal depression-related behavior,  abnormal blood vessel healing,  abnormal discrimination learning (details...)
Expression	Note Reference highly expressed in lung tissue 628503
Pathway	Ontology c-Jun N-terminal kinases MAPK signaling pathway,  Rho/Rac/Cdc42 mediated signaling pathway,  altered c-Jun N-terminal kinase MAPK signaling pathway (details...)
Product	Note Reference member of the activator protein-1 (AP-1) family of inducible nuclear proteins 628503
Regulation	Note Reference expression is increased by the treatment of amiodarone (AM), an iodinated benzofuran derivative and effective antidysrhythmic agent 628503 mRNA expression induced by estrogens 729283
Mutation/over- and underexpression	Note Reference overexpression increases gene expression involved in fibrotic tissue remodeling, such as collagen and collagenase 628503
External Links
Databases	DATABASE ID SOURCE SMART: BRLZ IPI PROSITE: BZIP_BASIC IPI PROSITE: BZIP IPI UNIPARC: UPI0000125BBE IPI KEGG Report: rno:24516 ENTREZGENE HomoloGene Group ID: 1679 ENTREZGENE Germonline: 2943 Pfam: Jun IPI Pfam: bZIP_1 IPI KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05211 ENTREZGENE KEGG Pathway: 05200 ENTREZGENE KEGG Pathway: 04722 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE InterPro: TF_bZIP. IPI InterPro: Leuzip_Jun. IPI InterPro: JNK. IPI InterPro: Euk_TF_DNA_bd. IPI InterPro: C_Jun. IPI InterPro: bZIP_1. IPI Ensembl Protein: ENSRNOP00000011732 IPI IPI: IPI00215370 IPI Entrez Gene: Jun ENTREZGENE IMAGE_CLONE: IMAGE:7124370 IMAGE-MGC_LOAD MGC_CLONE: MGC:93192 IMAGE-MGC_LOAD Ensembl Genes: ENSRNOG00000026293 IPI UniProt: JUN_RAT IPI RatMap: 34125 ENTREZGENE Superfamily-SCOP: Euk_transcr_DNA IPI PANTHER: C_Jun IPI PRINTS: LEUZIPPRJUN. IPI
Sequences	Nucleotide: X17163 Get FASTA Search GEO Profiles Nucleotide: CK475341 Get FASTA Search GEO Profiles Nucleotide: CB740532 Get FASTA Search GEO Profiles Nucleotide: BF414978 Get FASTA Search GEO Profiles Nucleotide: BE113912 Get FASTA Search GEO Profiles Nucleotide: BC078738 Get FASTA Search GEO Profiles Nucleotide: X17215 Get FASTA Search GEO Profiles Nucleotide: CH473998 Get FASTA Search GEO Profiles Nucleotide: NM_021835 Get FASTA Search GEO Profiles (View all 9 Nucleotide Accessions) Protein: P17325 Get FASTA Protein: CAA35041 Get FASTA Protein: AAH78738 Get FASTA Protein: CAA35084 Get FASTA Protein: EDL97766 Get FASTA Protein: NP_068607 Get FASTA (View all 6 Protein Accessions)
Clusters	UniGene: 93714
References
Curated References	51 references in RGD related to Jun
Other References	74 other references at PubMed related to Jun
Database Information
RGD ID	2943
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 17-NOV-05: Jun Jun oncogene v-jun sarcoma virus 17 oncogene homolog (avian) APPROVED Name updated 1299863 06-NOV-02: Jun v-jun sarcoma virus 17 oncogene homolog (avian) Avian sarcoma virus 17 (v-jun) oncogene homolog APPROVED Name updated 625702 10-JUN-02: Jun Avian sarcoma virus 17 (v-jun) oncogene homolog APPROVED Symbol and Name status set to approved 70586