RGD Reference Report - Sequence-specific impairment of learning by c-jun antisense oligonucleotides. - Rat Genome Database

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Sequence-specific impairment of learning by c-jun antisense oligonucleotides.

Authors: Tischmeyer, W  Grimm, R  Schicknick, H  Brysch, W  Schlingensiepen, KH 
Citation: Tischmeyer W, etal., Neuroreport. 1994 Jul 21;5(12):1501-4.
RGD ID: 2291844
Pubmed: PMID:7948848   (View Abstract at PubMed)

Hybridization studies revealed a differential accumulation of c-jun and jun B mRNA in the hippocampus and cerebral cortex of rats trained on a foot-shock-motivated brightness discrimination. Supposing that early gene expression is functionally significant for plastic changes in the brain, we used antisense phosphorothioate oligodeoxynucleotides (S-ODN) in vivo to study effects of specific inhibition of c-jun and jun B gene expression on learning and memory formation in rat brain. Discrimination performance of rats was impaired after intrahippocampal injection of anti-c-jun S-ODN but not of anti-jun B S-ODN. These results imply that topically injected antisense oligonucleotides affect processes involved in learning and memory in a sequence-specific manner.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
learning  IMP 2291844 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Jun  (Jun proto-oncogene, AP-1 transcription factor subunit)


Additional Information