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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases activityISOJun (Mus musculus)6480464CTDnickel sulfate results in increased activity of JUN proteinPMID:19131640
Junincreases expressionISOJun (Mus musculus)6480464CTDnickel sulfate results in increased expression of JUN mRNAPMID:19131640
Junincreases expressionISOJUN (Homo sapiens)6480464CTDnickel sulfate results in increased expression of JUN mRNAPMID:16314067 PMID:17382205
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDnickel sulfate results in increased phosphorylation of JUN proteinPMID:20493934
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDPotassium Dichromate inhibits the reaction [nickel sulfate results in increased phosphorylation of JUN protein]PMID:20493934
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