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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27385
Term: tetrachloromethane
Definition: A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.
Chemical ID: MESH:D002251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionEXP 6480464CTDCarbon Tetrachloride results in increased expression of JUN mRNAPMID:8825185 PMID:9398495
Junmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]; allyl sulfide inhibits the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]; Carbon Tetrachloride results in increased activity of [JUN protein binds to FOS protein]; Phenobarbital promotes the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]; pyridine promotes the reaction [Carbon Tetrachloride results in increased expression of JUN mRNA]PMID:8825185
Junincreases expressionISOJun (Mus musculus)6480464CTDCarbon Tetrachloride results in increased expression of JUN mRNA; Carbon Tetrachloride results in increased expression of JUN proteinPMID:10915739 PMID:15056808 PMID:20589743 PMID:21354444 PMID:25827057 PMID:27339419 PMID:31919559
Junmultiple interactionsISOJun (Mus musculus)6480464CTDCarbon Tetrachloride promotes the reaction [JUN protein binds to CHKA promoter]; Carbon Tetrachloride results in increased phosphorylation of and results in increased localization of JUN protein; ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased localization of JUN protein]; Plant Extracts inhibits the reaction [Carbon Tetrachloride results in increased expression of JUN protein]PMID:17728180 PMID:20589743 PMID:21291945
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