GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jun | multiple interactions | EXP | | 6480464 | CTD | Arsenic Trioxide promotes the reaction [Berberine affects the localization of JUN protein] | PMID:18294404 | Jun | affects expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the expression of JUN mRNA | PMID:12749819 | Jun | affects phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide affects the phosphorylation of JUN protein | PMID:25335113 | Jun | affects response to substance | ISO | JUN (Homo sapiens) | 6480464 | CTD | JUN mRNA affects the susceptibility to Arsenic Trioxide | PMID:23911876 | Jun | decreases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of JUN mRNA | PMID:19410645 | Jun | decreases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased expression of JUN mRNA; Arsenic Trioxide results in decreased expression of JUN protein | PMID:20471514 PMID:22521957 PMID:30093655 | Jun | decreases phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in decreased phosphorylation of JUN protein | PMID:21278055 | Jun | increases activity | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased activity of JUN protein | PMID:16646077 | Jun | increases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of JUN mRNA; Arsenic Trioxide results in increased expression of JUN protein; Arsenic Trioxide results in increased expression of JUN protein modified form | PMID:18633430 PMID:23883479 PMID:23911876 PMID:24956101 PMID:25258189 PMID:25574600 PMID:27829220 PMID:29442453 | Jun | increases phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of JUN protein | PMID:15637062 PMID:18210215 PMID:18633430 PMID:20074581 PMID:21655183 PMID:25174355 PMID:29266867 | Jun | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | Arsenic Trioxide promotes the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of JUN protein] | PMID:23106696 | Jun | multiple interactions | ISO | JUN (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; [[Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein] which binds to CDKN1A promoter; [Arsenic Trioxide co-treated with Bortezomib] results in decreased expression of JUN mRNA; [Arsenic Trioxide co-treated with Bortezomib] results in increased activity of JUN protein modified form; [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of JUN protein] which results in decreased expression of CDKN1A mRNA; [Arsenic Trioxide results in increased phosphorylation of JUN protein] which binds to HDAC1 protein; [Arsenic Trioxide results in increased phosphorylation of JUN protein] which results in decreased expression of CDKN1A; [Arsenic Trioxide results in increased phosphorylation of JUN protein] which results in decreased expression of CDKN1A mRNA; [Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN promoter] which binds to CDKN1A promoter]; Arsenic Trioxide promotes the reaction [[FOS protein binds to JUN protein] which results in increased expression of CDKN1A mRNA]; Arsenic Trioxide promotes the reaction [[JUN protein binds to CDKN1A promoter] which results in increased expression of CDKN1A protein]; Arsenic Trioxide promotes the reaction [JUN protein binds to TGIF1 protein]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUN mRNA]; Arsenic Trioxide promotes the reaction [nilotinib results in increased expression of JUN protein]; Arsenic Trioxide promotes the reaction [Tretinoin results in decreased expression of JUN protein]; Arsenic Trioxide results in increased expression of and results in increased phosphorylation of JUN protein; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of JUN protein; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [PRAM1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]]; Dasatinib promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein modified form]; HMOX1 protein inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of MMP9 mRNA]; JUN protein promotes the reaction [Arsenic Trioxide results in increased expression of MMP9 protein]; PRAM1 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [[Ethacrynic Acid co-treated with Arsenic Trioxide] results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased expression of JUN protein]; Tretinoin promotes the reaction [Arsenic Trioxide results in decreased expression of JUN protein]; zinc protoporphyrin promotes the reaction [Arsenic Trioxide results in increased expression of JUN protein] | PMID:15637062 PMID:17495969 PMID:18210215 PMID:18633430 PMID:18822310 PMID:20074581 PMID:21278055 PMID:23082001 PMID:23883479 PMID:24934751 PMID:25913414 PMID:27829220 PMID:29266867 PMID:30093655 | | ||||||||||||||||||||||
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