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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:68889
Term: hydroxytyrosol
Definition: A member of the class of catechols that is benzene-1,2-diol substituted by a 2-hydroxyethyl group at position 4. Isolated from Olea europaea, it exhibits antioxidant and antineoplastic activities.
Chemical ID: MESH:C005975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTD3,4-dihydroxyphenylethanol promotes the reaction [[Xanthine co-treated with XDH protein] results in decreased phosphorylation of JUN protein]PMID:26374991
Junincreases expressionISOJUN (Homo sapiens)6480464CTD3,4-dihydroxyphenylethanol results in increased expression of JUN mRNA; 3,4-dihydroxyphenylethanol results in increased expression of JUN protein; 3,4-dihydroxyphenylethanol results in increased expression of JUN protein modified formPMID:12482581
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