JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Chlorocebus sabaeus
Analyze
Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 18379433
Description: ENCODES a protein that exhibits cAMP response element binding (ortholog); chromatin binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); INVOLVED IN angiogenesis (ortholog); apoptotic process (ortholog); axon regeneration (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; fibroblast growth factor signaling pathway; ASSOCIATED WITH Alcohol-Related Disorders (ortholog); angiosarcoma (ortholog); Asphyxia (ortholog); FOUND IN chromatin (ortholog); euchromatin (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transcription factor AP-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
cell population proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to cadmium ion  (ISO)
cellular response to calcium ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion starvation  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to zinc ion starvation  (ISO)
circadian rhythm  (ISO)
DNA-templated transcription  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (ISO)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
outflow tract morphogenesis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of DNA-templated transcription initiation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA)
release from viral latency  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 60
Low 20
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007978554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCSAT00000018386   ⟹   ENSCSAP00000017843
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)Ensembl
RefSeq Acc Id: XM_007978554   ⟹   XP_007976745
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12074,204,481 - 74,207,835 (+)NCBI
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007976745 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017843
  ENSCSAP00000017843.1
RefSeq Acc Id: XP_007976745   ⟸   XM_007978554
- UniProtKB: A0A0D9SAF4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017843   ⟸   ENSCSAT00000018386


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000149 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018386.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  bZIP_sf UniProtKB/TrEMBL
  JNK UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/TrEMBL
KEGG Report csab:103224726 UniProtKB/TrEMBL
NCBI Gene JUN ENTREZGENE
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/TrEMBL
  PTHR11462:SF8 UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/TrEMBL
  Jun UniProtKB/TrEMBL
PRINTS LEUZIPPRJUN UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/TrEMBL
  SSF57959 UniProtKB/TrEMBL
UniProt A0A0D9SAF4 ENTREZGENE, UniProtKB/TrEMBL