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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943 Species: Rattus norvegicus RGD Object: Gene Symbol: Jun Name: jun proto-oncogene

Acc ID: CHEBI:32687 Term: piperonyl butoxide Definition: A benzodioxole that has formula C19H30O5. CasRN: 51-03-6 Chemical ID: MESH:D010882

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10828	6480464	CTD	[Piperonyl Butoxide co-treated with Diethylnitrosamine] results in increased expression of JUN mRNA	PMID:19690152
increases phosphorylation	ISO	RGD:10828	6480464	CTD	Piperonyl Butoxide results in increased phosphorylation of JUN protein	PMID:18228000