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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:30563
Term: silicon dioxide
Definition: A silicon oxide made up of linear triatomic molecules in which a silicon atom is covalently bonded to two oxygens.
Chemical ID: MESH:D012822
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects methylationISOJUN (Homo sapiens)6480464CTDSilicon Dioxide affects the methylation of JUN promoterPMID:27621875
Junincreases expressionISOJun (Mus musculus)6480464CTDSilicon Dioxide results in increased expression of JUN mRNAPMID:19073995 PMID:25949234 PMID:33720480
Junincreases expressionISOJUN (Homo sapiens)6480464CTDSilicon Dioxide results in increased expression of JUN mRNAPMID:21540303 PMID:22300531 PMID:25351596
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDSilicon Dioxide results in increased phosphorylation of JUN proteinPMID:35689653
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTD[SULF1 mRNA results in increased susceptibility to Silicon Dioxide] which results in increased expression of JUN mRNA; Acetylcysteine inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JUN protein]; JUN protein promotes the reaction [Silicon Dioxide results in decreased expression of SFTPA1 protein]; JUN protein promotes the reaction [Silicon Dioxide results in decreased expression of SFTPB protein]; pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased phosphorylation of JUN protein]PMID:29673857 PMID:35689653
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