GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jun | affects expression | EXP | | 6480464 | CTD | Acetaminophen affects the expression of JUN mRNA | PMID:18246545 | Jun | increases expression | EXP | | 6480464 | CTD | Acetaminophen results in increased expression of JUN mRNA | PMID:17202762 PMID:20732408 PMID:33387578 | Jun | affects expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Acetaminophen affects the expression of JUN mRNA | PMID:15606129 PMID:17562736 | Jun | affects expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Acetaminophen affects the expression of JUN mRNA | PMID:20732408 | Jun | decreases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Acetaminophen results in decreased expression of JUN mRNA | PMID:27761495 | Jun | increases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased expression of JUN mRNA; Acetaminophen results in increased expression of JUN protein | PMID:10915739 PMID:11264010 PMID:12540782 PMID:12774022 PMID:12958197 PMID:18544908 PMID:20363829 PMID:25265579 PMID:25949234 PMID:26056430 PMID:32045647 PMID:35166444 | Jun | increases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased expression of JUN mRNA | PMID:21420995 PMID:27761495 PMID:29067470 | Jun | increases phosphorylation | ISO | Jun (Mus musculus) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of JUN protein | PMID:20363829 | Jun | increases phosphorylation | ISO | JUN (Homo sapiens) | 6480464 | CTD | Acetaminophen results in increased phosphorylation of JUN protein | PMID:33959992 | Jun | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | [Clofibrate co-treated with Acetaminophen] affects the expression of JUN mRNA; Acetaminophen promotes the reaction [TNF protein results in increased expression of JUN mRNA]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of JUN mRNA]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of JUN mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of JUN mRNA]; saikosaponin D inhibits the reaction [Acetaminophen results in increased expression of JUN mRNA] | PMID:12540782 PMID:12774022 PMID:17585979 PMID:18700144 PMID:25265579 PMID:35166444 | Jun | multiple interactions | ISO | JUN (Homo sapiens) | 6480464 | CTD | [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in increased expression of JUN mRNA; N-acetylsphingosine promotes the reaction [Acetaminophen results in increased phosphorylation of JUN protein]; oltipraz inhibits the reaction [Acetaminophen results in increased phosphorylation of JUN protein]; pyrazolanthrone inhibits the reaction [Acetaminophen results in increased phosphorylation of JUN protein] | PMID:33819548 PMID:33959992 | | ||||||||||||||||||||||
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