GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Jun | decreases expression | EXP | | 6480464 | CTD | chromium hexavalent ion results in decreased expression of JUN protein | PMID:32679048 | Jun | affects expression | ISO | Jun (Mus musculus) | 6480464 | CTD | chromium hexavalent ion affects the expression of JUN mRNA | PMID:28472532 | Jun | increases expression | ISO | Jun (Mus musculus) | 6480464 | CTD | chromium hexavalent ion results in increased expression of JUN protein | PMID:19654923 | Jun | increases expression | ISO | JUN (Homo sapiens) | 6480464 | CTD | chromium hexavalent ion results in increased expression of JUN mRNA | PMID:27793765 | Jun | increases phosphorylation | ISO | Jun (Mus musculus) | 6480464 | CTD | chromium hexavalent ion results in increased phosphorylation of JUN protein | PMID:19654923 PMID:22472290 | Jun | multiple interactions | ISO | Jun (Mus musculus) | 6480464 | CTD | [chromium hexavalent ion promotes the reaction [JUN protein binds to PTGS2 promoter]] which results in increased expression of PTGS2 mRNA; Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; chromium hexavalent ion promotes the reaction [JUN protein binds to PTGS2 promoter]; IKBKB protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; JUN protein mutant form inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of NFKBIA protein]; MAP2K4 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein]; MAP2K7 protein promotes the reaction [chromium hexavalent ion results in increased phosphorylation of JUN protein] | PMID:19654923 PMID:22472290 | |
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