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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:2679
Term: amphetamine
Definition: A racemate comprising equimolar amounts of (R)-amphetamine (also known as levamphetamine or levoamphetamine) and (S)-amphetamine (also known as dexamfetamine or dextroamphetamine.
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases response to substanceEXP 6480464CTDJUN protein results in decreased susceptibility to AmphetaminePMID:16084549
Junincreases expressionEXP 6480464CTDAmphetamine results in increased expression of JUN mRNA; Amphetamine results in increased expression of JUN proteinPMID:16084549 PMID:8298093
Junincreases phosphorylationEXP 6480464CTDAmphetamine results in increased phosphorylation of JUN proteinPMID:15194466
Junmultiple interactionsEXP 6480464CTDJUN protein promotes the reaction [Amphetamine results in decreased expression of NPY mRNA]; JUN protein promotes the reaction [Amphetamine results in increased expression of SOD1 mRNA]; pyrazolanthrone inhibits the reaction [Amphetamine results in increased phosphorylation of JUN protein]PMID:15194466 PMID:16084549
Junincreases expressionISOJUN (Homo sapiens)6480464CTDAmphetamine results in increased expression of JUN proteinPMID:15814102
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDAmphetamine promotes the reaction [JUN protein binds to FOSB protein]; Amphetamine results in increased activity of [JUN protein binds to FOSB protein]PMID:15814102
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