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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:90705
Term: SB 203580
Definition: A member of the class of imidazoles carrying 4-methylsulfinylphenyl, 4-pyridyl and 4-fluorophenyl substituents at positions 2, 4 and 5 respectively. An inhibitor of mitogen-activated protein kinase.
Chemical ID: MESH:C093642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTDSB 203580 inhibits the reaction [Cadmium Chloride results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Phenylephrine results in increased expression of JUN mRNA]; SB 203580 promotes the reaction [diphenylarsinic acid results in increased expression of and results in increased phosphorylation of JUN protein]PMID:15252869 PMID:19002563 PMID:28087833
Junmultiple interactionsISOJun (Mus musculus)6480464CTDSB 203580 inhibits the reaction [icariin results in increased expression of JUN protein]; SB 203580 inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]PMID:11035063 PMID:18423597
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [benz(a)anthracene results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [benzo(k)fluoranthene results in increased expression of JUN mRNA]; SB 203580 inhibits the reaction [Glucose results in increased phosphorylation of JUN protein]; SB 203580 inhibits the reaction [indeno(1,2,3-cd)pyrene results in increased expression of JUN mRNA]PMID:19132243 PMID:21635667
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