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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionISOJUN (Homo sapiens)6480464CTDCatechin results in decreased expression of JUN mRNA; Catechin results in decreased expression of JUN proteinPMID:23706674
Junmultiple interactionsISOJun (Mus musculus)6480464CTDCatechin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of and results in increased phosphorylation of JUN protein]PMID:30453148
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