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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects expressionEXP 6480464CTDCocaine affects the expression of JUN proteinPMID:16179556
Junincreases expressionEXP 6480464CTDCocaine results in increased expression of JUN protein modified formPMID:17635674
Junincreases expressionISOJun (Mus musculus)6480464CTDCocaine results in increased expression of JUN proteinPMID:18355967
Junincreases expressionISOJUN (Homo sapiens)6480464CTDCocaine results in increased expression of JUN proteinPMID:15814102
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDCocaine promotes the reaction [JUN protein binds to FOSL2 protein]PMID:15814102
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