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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionISOJUN (Homo sapiens)6480464CTDafimoxifene results in increased expression of JUN mRNAPMID:19153601
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDafimoxifene results in increased phosphorylation of JUN proteinPMID:19935718
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [afimoxifene results in increased phosphorylation of JUN protein]; GPER1 protein affects the reaction [afimoxifene results in increased expression of JUN mRNA]PMID:19153601 PMID:19935718
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