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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionISOJUN (Homo sapiens)6480464CTDGenistein results in decreased expression of JUN proteinPMID:24685904
Junincreases activityISOJUN (Homo sapiens)6480464CTDGenistein results in increased activity of JUN proteinPMID:17088408
Junincreases expressionISOJUN (Homo sapiens)6480464CTDGenistein results in increased expression of JUN mRNAPMID:17266178
Junmultiple interactionsISOJun (Mus musculus)6480464CTDGenistein inhibits the reaction [Estradiol results in increased expression of JUN mRNA]PMID:11473722
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDGenistein inhibits the reaction [Oxygen deficiency results in increased expression of JUN mRNA]PMID:23452621
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