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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:34892
Term: nocodazole
Definition: A member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Chemical ID: MESH:D015739
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDNocodazole results in increased phosphorylation of JUN proteinPMID:12221076
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDTP53 protein affects the reaction [Nocodazole results in increased phosphorylation of JUN protein]PMID:12221076
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