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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:33234
Term: vitamin E
Definition: Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Chemical ID: MESH:D024502
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionISOJUN (Homo sapiens)6480464CTDVitamin E results in decreased expression of JUN mRNA; Vitamin E results in decreased expression of JUN proteinPMID:19244175 PMID:20015448
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDVitamin E results in increased phosphorylation of JUN proteinPMID:11522656
Junmultiple interactionsISOJun (Mus musculus)6480464CTDVitamin E promotes the reaction [Alcohols results in increased expression of JUN mRNA]PMID:18814483
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDRutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]PMID:20015448
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