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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:90369
Term: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
Definition: A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.
Chemical ID: MESH:C550547
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol promotes the reaction [JUN protein binds to REST promoter]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of JUN mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol results in increased expression of JUN protein modified form]PMID:26307266
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