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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of JUN mRNAPMID:20551477 PMID:30723492
Junincreases expressionISOJun (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of JUN mRNAPMID:15913567 PMID:30352267
Junmultiple interactionsISOJun (Mus musculus)6480464CTD1-Naphthylisothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein; 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; [C188-9 compound co-treated with 3-(5-(4-(cyclopentyloxy)-2-hydroxybenzoyl)-2-((3-hydroxy-1,2-benzisoxazol-6-yl)methoxy)phenyl)propionic acid] inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; C188-9 compound inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of and results in increased phosphorylation of JUN protein]; PPARA protein affects the reaction [1-Naphthylisothiocyanate results in increased expression of JUN mRNA]PMID:30352267 PMID:36460194
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