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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:18723
Term: nicotine
Definition: A racemate composed of equimolar amounts of (R)- and (S)-nicotine.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTDNicotine promotes the reaction [MAPK8 protein results in increased phosphorylation of JUN protein]PMID:17021677
Junincreases expressionISOJUN (Homo sapiens)6480464CTDNicotine results in increased expression of JUN proteinPMID:17003101
Junincreases phosphorylationISOJun (Mus musculus)6480464CTDNicotine results in increased phosphorylation of JUN proteinPMID:21511693
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDNicotine results in increased phosphorylation of JUN proteinPMID:34890707
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTD[U 0126 results in decreased activity of [MAPK1 protein co-treated with MAPK3 protein]] inhibits the reaction [Nicotine results in increased expression of JUN protein]; Nicotine inhibits the reaction [Cisplatin results in increased expression of JUN mRNA]PMID:11592233 PMID:17003101
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