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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:7553
Term: niclosamide
Definition: A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.
Chemical ID: MESH:D009534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junaffects localizationEXP 6480464CTDNiclosamide affects the localization of JUN proteinPMID:27338550
Junincreases expressionEXP 6480464CTDNiclosamide results in increased expression of JUN mRNAPMID:27338550
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDNiclosamide results in increased phosphorylation of JUN proteinPMID:24750999
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]]; Acetylcysteine inhibits the reaction [Niclosamide results in increased phosphorylation of JUN protein]; Hydrogen Peroxide promotes the reaction [Niclosamide results in increased phosphorylation of JUN protein]; JUN protein affects the reaction [Niclosamide results in increased cleavage of PARP1 protein]PMID:24750999
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