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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:338412
Term: (-)-anisomycin
Definition: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Chemical ID: MESH:D000841
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junincreases phosphorylationEXP 6480464CTDAnisomycin results in increased phosphorylation of JUN proteinPMID:9751194
Junincreases expressionISOJUN (Homo sapiens)6480464CTDAnisomycin results in increased expression of JUN mRNAPMID:18241849
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDAnisomycin results in increased phosphorylation of JUN proteinPMID:15019843 PMID:21815634 PMID:32780722
Junmultiple interactionsISOJUN (Homo sapiens)6480464CTDAnisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]PMID:11278392 PMID:32780722
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