Il10 (interleukin 10) - Rat Genome Database

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Gene: Il10 (interleukin 10) Rattus norvegicus
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Symbol: Il10
Name: interleukin 10
RGD ID: 2886
Description: Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of cellular biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); decubitus ulcer; liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10); PARTICIPATES IN Interleukin-10 signaling pathway; interleukin-4 signaling pathway; allograft rejection pathway; INTERACTS WITH (+)-pilocarpine; (-)-epigallocatechin 3-gallate; (2E,4E)-hexa-2,4-dienoic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CSIF; cytokine synthesis inhibitory factor; If2a; IL-10; IL10X; interferon 2a; interleukin-10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,024,921 - 45,029,586 (+)NCBIGRCr8
mRatBN7.21342,472,625 - 42,477,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,472,839 - 42,477,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,079,495 - 45,083,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,367,625 - 46,371,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,631,889 - 43,635,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,738,933 - 47,743,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,824,594 - 52,828,560 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,953,900 - 43,957,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,967,906 - 43,972,374 (+)NCBI
Celera1342,821,569 - 42,825,416 (+)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (IEP)
Actinic Cheilitis  (ISO)
Acute Experimental Pancreatitis  (IEP)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (IDA,IEP,ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
acute myocardial infarction  (IEP)
acute pancreatitis  (ISO)
adult respiratory distress syndrome  (IEP)
adult T-cell leukemia/lymphoma  (ISO)
aggressive periodontitis  (ISO)
Airway Obstruction  (ISO)
alcohol use disorder  (IEP)
allergic conjunctivitis  (ISO)
allergic contact dermatitis  (ISO)
allergic rhinitis  (ISO)
Alveolar Bone Loss  (IEP)
Alzheimer's disease  (ISO)
anemia  (ISO)
Animal Disease Models  (ISO)
anogenital venereal wart  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
aphthous stomatitis  (ISO)
appendicitis  (ISO)
arteriosclerosis  (ISO)
Asthenopia  (ISO)
asthma  (IEP,IGI,ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
autistic disorder  (ISO)
autoimmune hemolytic anemia  (ISO)
autoimmune hepatitis  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bacterial infectious disease  (ISO)
bacterial pneumonia  (ISO)
Behcet's disease  (ISO)
Brain Injuries  (IDA,ISO)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchus carcinoma  (ISO)
Burns  (IEP,ISO)
carotid artery disease  (ISO)
carotid stenosis  (ISO)
celiac disease  (ISO)
central nervous system lymphoma  (ISO)
cerebral infarction  (ISO)
cervical cancer  (ISO)
Chagas Cardiomyopathy  (IDA)
Chemically-Induced Disorders  (ISO)
cholangiocarcinoma  (ISO)
choroid disease  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Bronchitis  (IEP)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Chronic Periodontitis  (ISO)
colitis  (IEP,ISO)
colon cancer  (ISO)
common cold  (ISO)
common variable immunodeficiency 7  (ISO)
congestive heart failure  (IEP)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cutaneous leishmaniasis  (ISO)
cytomegalovirus retinitis  (ISO)
decubitus ulcer  (IEP)
diabetes mellitus  (ISO)
Diabetic Cardiomyopathies  (IDA)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
diffuse scleroderma  (ISO)
dilated cardiomyopathy  (IEP)
disseminated intravascular coagulation  (ISO)
drug allergy  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dry eye syndrome  (ISO)
Dysbiosis  (IEP)
Dyspepsia  (ISO)
Eales Disease  (ISO)
endometrial cancer  (ISO)
endometriosis  (IDA,ISO)
Endotoxemia  (IEP,ISO)
Entamoebiasis  (ISO)
Enterocolitis  (ISO)
Enterovirus Infections  (ISO)
esophageal cancer  (ISO)
Experimental Arthritis  (IDA,IEP,ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Autoimmune Uveitis  (IEP,ISO)
Experimental Autoimmune Uveoretinitis  (IDA,ISO)
Experimental Colitis  (IEP,ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,IMP,ISO)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (IDA,IEP)
Eye Burns  (IDA)
factor VIII deficiency  (ISO)
familial adult myoclonic epilepsy 5  (ISO)
Fanconi anemia  (ISO)
Femoral Fractures  (IEP)
gallbladder carcinoma  (ISO)
gastric dilatation  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
Genetic Predisposition to Disease  (ISO)
gestational diabetes  (ISO)
glomerulonephritis  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
graft-versus-host disease  (ISO)
granulomatosis with polyangiitis  (ISO)
Graves ophthalmopathy  (ISO)
Graves' disease  (ISO)
Hearing Loss  (IDA,ISO)
Heat Stroke  (ISO)
Hemorrhagic Shock  (IEP)
Heparin-induced Thrombocytopenia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (IDA,ISO)
herpes simplex virus keratitis  (ISO)
herpes zoster  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Human Viral Hepatitis  (ISO)
Hyperalgesia  (IDA,IEP,ISO)
hypertension  (IEP)
hyperthyroidism  (IEP,ISO)
Hypokalemic Periodic Paralysis, Type 1  (ISO)
hypothyroidism  (IEP)
ileitis  (ISO)
Immediate Hypersensitivity  (ISO)
Inflammation  (IEP,ISO)
inflammatory bowel disease  (ISO,ISS)
intermediate uveitis  (ISO)
intestinal obstruction  (IEP)
irritable bowel syndrome  (ISO)
Kidney Reperfusion Injury  (IDA,ISO)
leishmaniasis  (ISO)
leprosy  (ISO)
lip cancer  (ISO)
liver benign neoplasm  (IEP)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IDA)
lung disease  (IDA,IEP,ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoplasmacytic lymphoma  (ISO)
major depressive disorder  (ISO)
Malignant Pleural Effusions  (ISO)
metabolic dysfunction-associated steatohepatitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
middle cerebral artery infarction  (ISO)
Middle East respiratory syndrome  (ISO)
mitral valve stenosis  (ISO)
mucositis  (ISO)
multiple myeloma  (ISO)
Multiple Organ Failure  (ISO)
multiple sclerosis  (ISO)
Murine Acquired Immunodeficiency Syndrome  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP)
myocarditis  (IDA,ISO)
Nasal Polyps  (ISO)
Neoplasm Metastasis  (ISO)
Neuralgia  (IDA,IMP,ISO)
obesity  (IEP,ISO)
obstructive sleep apnea  (IEP)
occupational dermatitis  (ISO)
Ocular Toxoplasmosis  (ISO)
ocular tuberculosis  (ISO)
open-angle glaucoma  (ISO)
oral squamous cell carcinoma  (ISO)
otitis media  (IEP,ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (IEP)
panuveitis  (ISO)
parathyroid carcinoma  (ISO)
Penetrating Wounds  (IDA)
pericardial effusion  (ISO)
perinatal necrotizing enterocolitis  (IDA,ISO)
periodontitis  (IEP,ISO)
Plaque, Atherosclerotic  (ISO)
plasmacytoma  (ISO)
pleurisy  (ISO)
pneumonia  (ISO)
postpartum depression  (IEP)
Pregnancy-associated Malaria  (ISO)
primary biliary cholangitis  (ISO)
Primary Graft Dysfunction  (IDA)
Prostatic Neoplasms  (ISO)
prostatitis  (IEP,ISO)
Pseudomonas Aeruginosa Keratitis  (ISO)
psoriasis  (ISO)
pulmonary eosinophilia  (ISO)
pulmonary hypertension  (ISO)
Reperfusion Injury  (IDA,IEP,ISO)
respiratory allergy  (ISO)
respiratory syncytial virus infectious disease  (ISO)
retinal artery occlusion  (ISO)
retinal disease  (ISO)
retinopathy of prematurity  (ISO)
Retroviridae Infections  (ISO)
rheumatic heart disease  (ISO)
rheumatoid arthritis  (ISO)
Rhinosinusitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IDA,IEP,ISO)
severe acute respiratory syndrome  (IEP,ISO)
shigellosis  (ISO)
Shwartzman phenomenon  (ISO)
sickle cell anemia  (ISO)
Sjogren's syndrome  (ISO)
skin disease  (ISO)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
Staphylococcal Infections  (IDA)
Staphylococcal Pneumonia  (ISO)
steatotic liver disease  (IEP)
stomach cancer  (ISO)
Stroke  (IDA,IEP,ISO)
systemic lupus erythematosus  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
thyrotoxicosis  (IEP)
tongue squamous cell carcinoma  (IEP)
toxic encephalopathy  (IDA)
toxic shock syndrome  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
transient cerebral ischemia  (IDA)
Transplant Rejection  (IDA,ISO)
trichinosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uveitis  (ISO)
vasculitis  (ISO)
Venous Thrombosis  (ISO)
Ventilator-Induced Lung Injury  (IDA)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Weight Loss  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-Tetrandrine  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitrobenzene  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (ISO)
2,5-dihydroxybenzoic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-chloroethanol  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylprop-2-enal  (ISO)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-chloro-m-cresol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-methylhistamine  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-phenylbutyric acid  (ISO)
4-tolyl isocyanate  (ISO)
5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol  (ISO)
5-aminoimidazole-4-carboxamide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
7-ketocholesterol  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
actinomycin D  (ISO)
adapalene  (ISO)
adenosine  (ISO)
adenosine 5'-[gamma-thio]triphosphate  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
Aflatoxin G1  (ISO)
agathisflavone  (EXP)
albendazole  (ISO)
albuterol  (EXP)
all-trans-retinoic acid  (ISO)
all-trans-retinyl palmitate  (ISO)
alloxan  (ISO)
alpha-D-galactose  (ISO)
alpha-galactosylceramide  (ISO)
alpha-naphthoflavone  (ISO)
aluminium oxide  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonium chloride  (EXP)
Ammothamnine  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperentin  (ISO)
asperuloside  (ISO)
astaxanthin  (EXP,ISO)
atrazine  (ISO)
Bardoxolone methyl  (ISO)
Bavachinin  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzocaine  (ISO)
berberine  (EXP,ISO)
Bergenin  (EXP)
beryllium sulfate  (ISO)
beta-D-glucan  (ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisoprolol  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
boron atom  (EXP)
bortezomib  (ISO)
BQ 123  (ISO)
bryostatin 1  (ISO)
bucladesine  (ISO)
butachlor  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
caffeine  (ISO)
calciol  (EXP,ISO)
calcitriol  (EXP,ISO)
Calcium propionate  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbachol  (ISO)
carbamate ester  (ISO)
Carbaprostacyclin  (ISO)
carbendazim  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
carrageenan  (EXP,ISO)
carteolol  (ISO)
carvedilol  (EXP,ISO)
catechol  (ISO)
cefotaxime  (ISO)
cefoxitin  (ISO)
ceftazidime pentahydrate  (ISO)
cefuroxime  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (EXP)
CGS-21680  (ISO)
chenodeoxycholic acid  (ISO)
chitosan  (ISO)
chloroethene  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chromium atom  (EXP)
chrysin  (EXP,ISO)
ciprofloxacin  (EXP,ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP)
clenbuterol  (EXP,ISO)
clodronic acid  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
cordycepin  (ISO)
cortisol  (ISO)
costunolide  (ISO)
coumarins  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloastragenol  (EXP)
cycloheximide  (EXP,ISO)
Cyclopamine  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
D-penicillamine  (EXP)
danazol  (EXP)
dantrolene  (EXP,ISO)
dapagliflozin  (EXP)
DAPT  (EXP)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP)
dexamethasone  (ISO)
dexamethasone phosphate  (EXP)
dextran  (ISO)
dextran sulfate  (EXP,ISO)
dextromethorphan  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
diazoxide  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicyclohexylmethane-4,4'-diisocyanate  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP)
diethyl maleate  (ISO)
diethyl phthalate  (EXP,ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (ISO)
dimethoate  (ISO)
dioxygen  (EXP,ISO)
diphenylmethane-4,4'-diisocyanate  (ISO)
diprotium oxide  (EXP)
disodium selenite  (EXP)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
dydrogesterone  (ISO)
edaravone  (EXP)
elemental boron  (EXP)
elemental selenium  (EXP,ISO)
emamectin benzoate  (ISO)
emodin  (ISO)
estriol  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethionamide  (EXP)
eticlopride(1+)  (EXP)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
famotidine  (ISO)
fasudil  (EXP)
flavonoids  (ISO)
flurbiprofen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (EXP,ISO)
formoterol fumarate  (EXP)
fragrance  (ISO)
fructose  (EXP)
fucoidan  (EXP)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
galanthamine  (EXP)
gemcitabine  (ISO)
gemfibrozil  (EXP)
Geniposide  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geraniol  (ISO)
gliclazide  (EXP)
glucuronoxylomannan  (ISO)
glutathione  (ISO)
glycocholic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
graphite  (ISO)
haloperidol  (ISO)
helenalin  (ISO)
heroin  (ISO)
hexachlorobenzene  (EXP,ISO)
hexadecanoic acid  (ISO)
hexamethylene diisocyanate  (ISO)
histamine  (ISO)
HU-308  (EXP,ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
hydroxylamine  (EXP)
hydroxysafflor yellow A  (ISO)
hypochlorous acid  (ISO)
ibrutinib  (ISO)
ibuprofen  (ISO)
IC-87114  (ISO)
idelalisib  (ISO)
imidacloprid  (EXP)
imipramine  (ISO)
imiquimod  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
ionomycin  (EXP,ISO)
irinotecan  (EXP,ISO)
isatin  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isophorone diisocyanate  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
kaempferol  (EXP)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (EXP)
ketoprofen  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (ISO)
leflunomide  (ISO)
letrozole  (EXP)
leukotriene B4  (ISO)
linagliptin  (EXP)
linoleic acid  (ISO)
linuron  (ISO)
lipoic acid  (EXP)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
losartan  (EXP)
lupeol  (ISO)
luteolin  (ISO)
lycopene  (ISO)
mangiferin  (EXP)
mechlorethamine  (EXP)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
mesalamine  (EXP)
metam  (ISO)
metformin  (EXP,ISO)
methadone  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl isocyanate  (ISO)
methyl isothiocyanate  (ISO)
methyl methanesulfonate  (ISO)
Methyl palmitate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
metronidazole  (ISO)
metyrapone  (EXP)
microcystin-LR  (EXP,ISO)
mifepristone  (ISO)
minocycline  (EXP,ISO)
misoprostol  (ISO)
mitogen  (EXP,ISO)
MK-2206  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotaline  (EXP,ISO)
Monocyte locomotion inhibitory factor  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
Morroniside  (EXP,ISO)
mycophenolic acid  (EXP)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-dimethylacetamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP,ISO)
nadolol  (ISO)
naproxen  (EXP)
naringin  (EXP,ISO)
neostigmine  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nicotinamide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
Nonylphenol  (ISO)
notoginsenoside R1  (ISO)
NS-398  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
olanzapine  (ISO)
Olmesartan medoxomil  (EXP)
omeprazole  (ISO)
oridonin  (EXP)
orlistat  (EXP)
oroxylin A  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP,ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
paroxetine  (ISO)
patchouli alcohol  (EXP)
patulin  (ISO)
pentachlorophenol  (ISO)
pentamidine  (ISO)
Pentoxifylline  (ISO)
peptidoglycan  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perindopril  (EXP,ISO)
permethrin  (EXP)
phenanthrene  (EXP)
phenanthridone  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP)
phloretin  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (EXP)
phosphatidylcholine  (ISO)
phthalaldehyde  (ISO)
phthalic anhydride  (ISO)
pinostrobin  (EXP)
pioglitazone  (EXP,ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (EXP,ISO)
polymyxin B2  (ISO)
polyphosphates  (ISO)
pomalidomide  (ISO)
potassium chloride  (EXP)
prednisolone  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
progesterone  (ISO)
propamocarb  (ISO)
propionic acid  (EXP,ISO)
propofol  (ISO)
propranolol  (EXP)
prostaglandin E2  (ISO)
prostaglandin F2alpha  (ISO)
prostaglandin I2  (EXP)
protein kinase inhibitor  (ISO)
pyocyanine  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (EXP,ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
ranitidine  (EXP,ISO)
raspberry ketone  (EXP)
rebaudioside A  (EXP)
reserpine  (ISO)
resiniferatoxin  (EXP)
resiquimod  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ribavirin  (EXP,ISO)
rifampicin  (EXP)
rifaximin  (ISO)
rimonabant  (ISO)
Ro 41-5253  (ISO)
rolipram  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitrosoglutathione  (ISO)
SB 203580  (ISO)
SCH 23390  (ISO)
scopolamine  (ISO)
scopoletin  (EXP)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
sevoflurane  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP,ISO)
Sinomenine  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (ISO)
sodium benzoate  (EXP)
sodium dichromate  (ISO)
Sodium salicylate  (ISO)
sodium stibogluconate  (ISO)
spironolactone  (ISO)
SR 144528  (ISO)
sterigmatocystin  (EXP,ISO)
stigmasterol  (ISO)
streptozocin  (EXP,ISO)
sucrose  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulfoxaflor  (EXP)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
sunitinib  (EXP,ISO)
suramin  (ISO)
synephrine  (ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tamibarotene  (EXP)
tangeretin  (EXP)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (ISO)
taurocholic acid  (ISO)
taurodeoxycholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
telmisartan  (EXP)
terbufos  (ISO)
terbutaline  (ISO)
Terfenadine  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
thalidomide  (ISO)
Theaflavin 3,3'-digallate  (ISO)
theophylline  (ISO)
thiacloprid  (EXP)
thioacetamide  (EXP,ISO)
thymol  (EXP)
thymol sulfate(1-)  (EXP)
thymoquinone  (EXP)
thyroxine  (EXP)
titanium dioxide  (ISO)
TMC-120A  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
trans-caffeic acid  (ISO)
trans-rhaponticin  (EXP)
tributylstannane  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (EXP)
triclocarban  (ISO)
trimellitic anhydride  (ISO)
trimethyltin  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
uranium atom  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valproic acid  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vinorelbine  (ISO)
vitamin E  (EXP,ISO)
water  (EXP)
WIN 55212-2  (EXP,ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in labyrinthine layer morphogenesis  (ISO)
cellular response to antibiotic  (ISO)
cellular response to estradiol stimulus  (IEP)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to virus  (ISO)
chronic inflammatory response to antigenic stimulus  (ISO)
defense response to bacterium  (ISO)
defense response to protozoan  (ISO)
immune response  (IMP)
interleukin-10-mediated signaling pathway  (ISO)
liver regeneration  (IEP)
negative regulation of apoptotic process  (IMP)
negative regulation of autophagy  (ISO)
negative regulation of B cell proliferation  (ISO,ISS)
negative regulation of cell population proliferation  (ISO)
negative regulation of chronic inflammatory response to antigenic stimulus  (ISO)
negative regulation of cytokine production  (IMP,ISO)
negative regulation of cytokine production involved in immune response  (ISO,ISS)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of heterotypic cell-cell adhesion  (ISO)
negative regulation of inflammatory response  (ISO,ISS)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-6 production  (ISO,ISS)
negative regulation of membrane protein ectodomain proteolysis  (ISO,ISS)
negative regulation of MHC class II biosynthetic process  (ISO)
negative regulation of myeloid dendritic cell activation  (ISO)
negative regulation of neuron apoptotic process  (IDA)
negative regulation of nitric oxide biosynthetic process  (IDA)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (IDA,ISO)
negative regulation of type II interferon production  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of B cell apoptotic process  (ISO,ISS)
positive regulation of cell cycle  (ISO)
positive regulation of cytokine production  (ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of macrophage activation  (IDA)
positive regulation of MHC class II biosynthetic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of plasma cell differentiation  (ISO)
positive regulation of receptor signaling pathway via JAK-STAT  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of complement-dependent cytotoxicity  (ISO)
regulation of gene expression  (ISO)
regulation of response to wounding  (ISO)
regulation of synapse organization  (IDA)
response to activity  (IEP)
response to carbon monoxide  (IEP)
response to glucocorticoid  (IEP,ISO,ISS)
response to inactivity  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to molecule of bacterial origin  (ISS)
response to organic substance  (IEP)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)

Cellular Component
extracellular space  (IDA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. Abu El-Asrar AM, etal., Cytokine. 2012 Aug;59(2):377-81. doi: 10.1016/j.cyto.2012.04.030. Epub 2012 May 12.
2. Molecular analysis of interleukin-10 gene polymorphisms in patients with Behçet's disease. Afkari B, etal., Immunol Lett. 2018 Feb;194:56-61. doi: 10.1016/j.imlet.2017.12.008. Epub 2017 Dec 30.
3. Abrogation of anti-retinal autoimmunity in IL-10 transgenic mice due to reduced T cell priming and inhibition of disease effector mechanisms. Agarwal RK, etal., J Immunol. 2008 Apr 15;180(8):5423-9.
4. Down-regulation of IFN-gamma-producing CD56+ T cells after combined low-dose cyclosporine/prednisone treatment in patients with Behcet's uveitis. Ahn JK, etal., Invest Ophthalmol Vis Sci. 2005 Jul;46(7):2458-64.
5. Hypermethylation of IL-10 gene is responsible for its low mRNA expression in Behçet's disease. Alipour S, etal., J Cell Biochem. 2018 Aug;119(8):6614-6622. doi: 10.1002/jcb.26809. Epub 2018 May 2.
6. Cytokine polymorphisms predict the frequency of otitis media as a complication of rhinovirus and RSV infections in children. Alper CM, etal., Eur Arch Otorhinolaryngol. 2009 Feb;266(2):199-205. doi: 10.1007/s00405-008-0729-2. Epub 2008 Jun 17.
7. Anti-inflammatory cytokines in subclinical carotid atherosclerosis. Ambrosius W, etal., Neurology. 2006 Jun 27;66(12):1946-8.
8. Genetic variants in inflammation pathway genes and asthma in glioma susceptibility. Amirian E, etal., Neuro Oncol. 2010 May;12(5):444-52. Epub 2010 Feb 5.
9. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. Amu S, etal., J Allergy Clin Immunol. 2010 May;125(5):1114-1124.e8. Epub 2010 Mar 20.
10. Interleukin 10 (IL-10) influences autoimmune response in primary Sjogren's syndrome and is linked to IL-10 gene polymorphism. Anaya JM, etal., J Rheumatol. 2002 Sep;29(9):1874-6.
11. Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ). Andrade EF, etal., Nutrients. 2018 Nov 7;10(11). pii: nu10111702. doi: 10.3390/nu10111702.
12. Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. Apte RS, etal., PLoS Med. 2006 Aug;3(8):e310.
13. Dysregulated phosphorylation and nuclear translocation of cyclic AMP response element binding protein (CREB) in rat liver after chronic ethanol binge. Aroor AR, etal., Eur J Pharmacol. 2012 Mar 15;679(1-3):101-8. doi: 10.1016/j.ejphar.2011.12.045. Epub 2012 Jan 15.
14. TNF-α and IL-10 polymorphisms increase the risk to hepatocellular carcinoma in HCV infected individuals. Aroucha DC, etal., J Med Virol. 2016 Sep;88(9):1587-95. doi: 10.1002/jmv.24501. Epub 2016 Mar 21.
15. Cytokine polymorphism in noninfectious uveitis. Atan D, etal., Invest Ophthalmol Vis Sci. 2010 Aug;51(8):4133-42. doi: 10.1167/iovs.09-4583. Epub 2010 Mar 24.
16. Punctate inner choroidopathy and multifocal choroiditis with panuveitis share haplotypic associations with IL10 and TNF loci. Atan D, etal., Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3573-81. doi: 10.1167/iovs.10-6743.
17. Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. Athale J, etal., Free Radic Biol Med. 2012 Oct 15;53(8):1584-94. doi: 10.1016/j.freeradbiomed.2012.08.009. Epub 2012 Aug 23.
18. Dysregulated Lysine Acetyltransferase 2B Promotes Inflammatory Bowel Disease Pathogenesis Through Transcriptional Repression of Interleukin-10. Bai AH, etal., J Crohns Colitis. 2016 Jun;10(6):726-34. doi: 10.1093/ecco-jcc/jjw020. Epub 2016 Jan 22.
19. The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. Balding J, etal., Ir J Med Sci. 2004 Oct-Dec;173(4):200-3.
20. Polymorphisms in the TNF-alpha and IL10 gene promoters and risk of arsenic-induced skin lesions and other nondermatological health effects. Banerjee N, etal., Toxicol Sci. 2011 May;121(1):132-9. doi: 10.1093/toxsci/kfr046. Epub 2011 Feb 25.
21. The impact of the IL-1β, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype. Barış S, etal., Med Clin (Barc). 2016 May 6;146(9):379-83. doi: 10.1016/j.medcli.2015.09.017. Epub 2015 Dec 3.
22. Single nucleotide polymorphism rs1800872 in the promoter region of the IL10 gene is associated with predisposition to chronic hepatitis C in Russian population. Barkhash AV, etal., Microbes Infect. 2018 Mar;20(3):212-216. doi: 10.1016/j.micinf.2017.11.012. Epub 2017 Dec 14.
23. Poly (lactide-co-glycolide)-polymethacrylate nanoparticles for intramuscular delivery of plasmid encoding interleukin-10 to prevent autoimmune diabetes in mice. Basarkar A and Singh J, Pharm Res. 2009 Jan;26(1):72-81. Epub 2008 Sep 9.
24. Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge. Baumann R, etal., Am J Rhinol Allergy. 2013 Jul-Aug;27(4):266-72. doi: 10.2500/ajra.2013.27.3913.
25. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. Berg DJ, etal., J Clin Invest. 1995 Nov;96(5):2339-47.
26. Effects of indomethacin-loaded nanocapsules in experimental models of inflammation in rats. Bernardi A, etal., Br J Pharmacol. 2009 May 6.
27. DABIL-2 suppresses autoimmune inflammation in the CNS and inhibits T cell-mediated lysis of glial target cells. Bhopale MK, etal., Exp Mol Pathol. 2013 Jul 17. pii: S0014-4800(13)00090-7. doi: 10.1016/j.yexmp.2013.07.004.
28. Murine cytomegalovirus downregulates interleukin-17 in mice with retrovirus-induced immunosuppression that are susceptible to experimental cytomegalovirus retinitis. Blalock EL, etal., Cytokine. 2013 Mar;61(3):862-75. doi: 10.1016/j.cyto.2013.01.009. Epub 2013 Feb 14.
29. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blazar BR, etal., Blood. 1995 Feb 1;85(3):842-51.
30. Intestinal infection with Trichinella spiralis induces distinct, regional immune responses. Blum LK, etal., Vet Parasitol. 2013 May 20;194(2-4):101-5. doi: 10.1016/j.vetpar.2013.01.030. Epub 2013 Feb 5.
31. Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis. Bocsan IC, etal., Oxid Med Cell Longev. 2017;2017:4297206. doi: 10.1155/2017/4297206. Epub 2017 Aug 9.
32. Down-modulation of lung immune responses by interleukin-10 and transforming growth factor beta (TGF-beta) and analysis of TGF-beta receptors I and II in active tuberculosis. Bonecini-Almeida MG, etal., Infect Immun. 2004 May;72(5):2628-34.
33. Dysregulation in myelination mediated by persistent neuroinflammation: Possible mechanisms in chemotherapy-related cognitive impairment. Briones TL and Woods J, Brain Behav Immun. 2013 Aug 2. pii: S0889-1591(13)00409-1. doi: 10.1016/j.bbi.2013.07.175.
34. Telmisartan Prevents Alveolar Bone Loss by Decreasing the Expression of Osteoclasts Markers in Hypertensive Rats With Periodontal Disease. Brito VGB, etal., Front Pharmacol. 2020 Nov 11;11:579926. doi: 10.3389/fphar.2020.579926. eCollection 2020.
35. Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Broderick CA, etal., Mol Ther. 2005 Aug;12(2):369-73.
36. IL-10 delivery by AAV5 vector attenuates inflammation in mice with Pseudomonas pneumonia. Buff SM, etal., Gene Ther. 2010 May;17(5):567-76. Epub 2010 Apr 1.
37. Clinical and immunological correlates of pre-co-seasonal sublingual immunotherapy with birch monomeric allergoid in patients with allergic rhinoconjunctivitis. Burastero SE, etal., Int J Immunopathol Pharmacol. 2009 Apr-Jun;22(2):343-52.
38. Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala. Burke NN, etal., Genes Brain Behav. 2013 Aug 19. doi: 10.1111/gbb.12080.
39. An Analysis of IL-10/IL-10R Genetic Factors Related to Risk of Colon Cancer and Inflammatory Bowel Disease in a Han Chinese Population. Cai J and Zhang Z, Clin Lab. 2016;62(6):1147-54.
40. Exercise training improves the IL-10/TNF-α cytokine balance in the gastrocnemius of rats with heart failure. Calegari L, etal., Braz J Phys Ther. 2018 Mar - Apr;22(2):154-160. doi: 10.1016/j.bjpt.2017.09.004. Epub 2017 Sep 7.
41. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Caligiuri G, etal., Mol Med. 2003 Jan-Feb;9(1-2):10-7.
42. Mechanisms of dexamethasone to protect flaps from an ischemia-reperfusion injury. Cao J, etal., Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2006 Jun;20(6):661-5.
43. IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B. Cao LN, etal., Genet Mol Res. 2016 Feb 22;15(1). pii: gmr7256. doi: 10.4238/gmr.15017256.
44. Effects of Cissampelos sympodialis Eichl. and its Alkaloid, Warifteine, in an Experimental Model of Respiratory Allergy to Blomia tropicalis. Cerqueira-Lima AT, etal., Curr Drug Targets. 2010 Jun 28.
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303. Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model. Tsuchiya K, etal., Ann Otol Rhinol Laryngol. 2008 Aug;117(8):630-6.
304. Music exposure induced prolongation of cardiac allograft survival and generated regulatory CD4(+) cells in mice. Uchiyama M, etal., Transplant Proc. 2012 May;44(4):1076-9. doi: 10.1016/j.transproceed.2012.02.008.
305. Interleukin-10 induction after combined resection of liver and pancreas. Uchiyama T, etal., Hepatogastroenterology. 2001 Nov-Dec;48(42):1705-10.
306. Interleukin 10 deficiency attenuates induction of anti-TSH receptor antibodies and hyperthyroidism in a mouse Graves' model. Ueki I, etal., J Endocrinol. 2011 Jun;209(3):353-7. doi: 10.1530/JOE-11-0129. Epub 2011 Apr 7.
307. Osteopontin levels are elevated in patients with eosinophilic pneumonia. Ueno T, etal., Respirology. 2010 Aug 26.
308. Clarithromycin and telithromycin increases interleukin-10 expression in the rat endometriosis model. Umezawa M, etal., Cytokine. 2011 Sep;55(3):339-42. doi: 10.1016/j.cyto.2011.05.014. Epub 2011 Jun 12.
309. Dominance of high-producing interleukin 6 and low-producing interleukin 10 and interferon gamma alleles in glucose-6-phosphate dehydrogenase-deficient trauma patients. Upperman JS, etal., Shock. 2005 Mar;23(3):197-201.
310. Relationship between circulating interleukin-10 (IL-10) with interleukin-6 (IL-6) type cytokines (IL-6, interleukin-11 (IL-11), oncostatin M (OSM)) and soluble interleukin-6 (IL-6) receptor (sIL-6R) in patients with multiple myeloma. Urbanska-Rys H, etal., Eur Cytokine Netw. 2000 Sep;11(3):443-51.
311. Intraocular and serum cytokine profiles in patients with intermediate uveitis. Valentincic NV, etal., Mol Vis. 2011;17:2003-10. Epub 2011 Jul 20.
312. The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C. Vieira DA, etal., Qual Life Res. 2019 Jun;28(6):1531-1542. doi: 10.1007/s11136-019-02129-5. Epub 2019 Feb 7.
313. Correlation between inflammatory mediators in the nasopharyngeal secretion and in the serum of children with lower respiratory tract infection caused by respiratory syncytial virus and disease severity. Vieira RA, etal., J Bras Pneumol. 2010 Feb;36(1):59-66.
314. Is IL-10-819C/T gene polymorphism modulating the risk of gallbladder disease in north Indian population? Vishnoi M, etal., J Gastrointest Cancer. 2007;38(1):46-51.
315. PACAP Attenuates NMDA-Induced Retinal Damage in Association with Modulation of the Microglia/Macrophage Status into an Acquired Deactivation Subtype. Wada Y, etal., J Mol Neurosci. 2013 Oct;51(2):493-502. doi: 10.1007/s12031-013-0017-5. Epub 2013 May 30.
316. Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+CD25+Treg cells. Wang B, etal., Int J Biochem Cell Biol. 2014 Oct;55:98-108. doi: 10.1016/j.biocel.2014.08.014. Epub 2014 Aug 25.
317. The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock. Wang F, etal., Scand J Immunol. 2017 Apr;85(4):258-263. doi: 10.1111/sji.12515.
318. YB-1 orchestrates onset and resolution of renal inflammation via IL10 gene regulation. Wang J, etal., J Cell Mol Med. 2017 Dec;21(12):3494-3505. doi: 10.1111/jcmm.13260. Epub 2017 Jun 30.
319. Long Noncoding RNA H19 Promotes Neuroinflammation in Ischemic Stroke by Driving Histone Deacetylase 1-Dependent M1 Microglial Polarization. Wang J, etal., Stroke. 2017 Aug;48(8):2211-2221. doi: 10.1161/STROKEAHA.117.017387. Epub 2017 Jun 19.
320. IL-10 enhances CTL-mediated tumor rejection by inhibiting highly suppressive CD4 T cells and promoting CTL persistence in a murine model of plasmacytoma. Wang L, etal., Oncoimmunology. 2015 May 13;4(7):e1014232. eCollection 2015 Jul.
321. Intraperitoneal injection (IP), Intravenous injection (IV) or anal injection (AI)? Best way for mesenchymal stem cells transplantation for colitis. Wang M, etal., Sci Rep. 2016 Aug 4;6:30696. doi: 10.1038/srep30696.
322. Influences of intestinal ligation on bacterial translocation and inflammatory response in rats with hemorrhagic shock: implications for damage control surgery. Wang P, etal., J Invest Surg. 2008 Sep-Oct;21(5):244-54.
323. Treatment and prevention of experimental autoimmune myocarditis with CD28 superagonists. Wang S, etal., Cardiology. 2010;115(2):107-13. doi: 10.1159/000256660. Epub 2009 Nov 10.
324. [Changes of IL-2, IL-8, IL-10 and TNF-alpha levels in sera of patients with acute graft-versus-host disease]. Wang SH, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006 Aug;14(4):755-8.
325. (-)-Epigallocatechin-3-Gallate Ameliorates Atherosclerosis and Modulates Hepatic Lipid Metabolic Gene Expression in Apolipoprotein E Knockout Mice: Involvement of TTC39B. Wang W, etal., Front Pharmacol. 2018 Mar 9;9:195. doi: 10.3389/fphar.2018.00195. eCollection 2018.
326. [The association between single-nucleotide polymorphisms in IL6, IL10 genes and the susceptibility to primary hepatic carcinoma in Shunde District of Foshan City]. Wang XL, etal., Zhonghua Yu Fang Yi Xue Za Zhi. 2017 Aug 6;51(8):698-702. doi: 10.3760/cma.j.issn.0253-9624.2017.08.008.
327. Protective effect of glucose-insulin-potassium (GIK) on intestinal tissues after severe burn in experimental rats. Wang Z, etal., Burns. 2012 Sep;38(6):846-54. doi: 10.1016/j.burns.2011.12.015. Epub 2012 Feb 15.
328. Endogenous regulation of the acute inflammatory response. Ward PA and Lentsch AB, Mol Cell Biochem 2002 May-Jun;234-235(1-2):225-8.
329. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
330. Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice. Watanabe N, etal., J Exp Med. 2002 Jul 1;196(1):141-6.
331. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
332. Haplotype-tagging interleukin-10 promoter polymorphism is associated with reduced risk of retinal artery occlusion. Weger M, etal., Mol Vis. 2007 Apr 4;13:549-52.
333. The antinociceptive efficacy of HWTX-I epidurally administered in rheumatoid arthritis rats. Wen Tao Z, etal., Int J Sports Med. 2011 Nov;32(11):869-74. doi: 10.1055/s-0031-1280775. Epub 2011 Nov 3.
334. Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora. Whary MT, etal., Infect Immun. 2006 Dec;74(12):6615-23. Epub 2006 Sep 18.
335. Attenuation of lipopolysaccharide-induced acute lung injury by treatment with IL-10. Wu CL, etal., Respirology. 2009 Apr 5.
336. Expression of interleukin-10 splicing variants is a positive prognostic feature in relapsed childhood acute lymphoblastic leukemia. Wu S, etal., J Clin Oncol. 2005 May 1;23(13):3038-42.
337. IL-10 promotes malignant pleural effusion in mice by regulating TH 1- and TH 17-cell differentiation and migration. Wu XZ, etal., Eur J Immunol. 2019 Apr;49(4):653-665. doi: 10.1002/eji.201847685. Epub 2019 Feb 12.
338. Dietary GD3 Ganglioside Reduces the Incidence and Severity of Necrotizing Enterocolitis (NEC) by Sustaining Regulatory Immune Responses. Xu J, etal., J Pediatr Gastroenterol Nutr. 2013 Jun 18.
339. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
340. Combined treatment with bone marrow mesenchymal stem cells and methylprednisolone in paraquat-induced acute lung injury. Yang H, etal., BMC Emerg Med. 2013;13 Suppl 1:S5. doi: 10.1186/1471-227X-13-S1-S5. Epub 2013 Jul 4.
341. Therapeutic effect of Ginkgo biloba polysaccharide in rats with focal cerebral ischemia/reperfusion (I/R) injury. Yang Y, etal., Carbohydr Polym. 2013 Nov 6;98(2):1383-8. doi: 10.1016/j.carbpol.2013.07.045. Epub 2013 Jul 29.
342. Activation of the Notch signaling pathway disturbs the CD4+/CD8+, Th17/Treg balance in rats with experimental autoimmune uveitis. Yin X, etal., Inflamm Res. 2019 Sep;68(9):761-774. doi: 10.1007/s00011-019-01260-w. Epub 2019 Jun 17.
343. Role of IL-10 in regulating proinflammatory cytokine release by Kupffer cells following trauma-hemorrhage. Yokoyama Y, etal., Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G942-6. Epub 2004 Jan 8.
344. Local Induction of B Cell Interleukin-10 Competency Alleviates Inflammation and Bone Loss in Ligature-Induced Experimental Periodontitis in Mice. Yu P, etal., Infect Immun. 2016 Dec 29;85(1). pii: IAI.00645-16. doi: 10.1128/IAI.00645-16. Print 2017 Jan.
345. Marrow mesenchymal stem cells reduce methicillin-resistant Staphylococcus aureus infection in rat models. Yuan Y, etal., Cytotherapy. 2013 Aug 30. pii: S1465-3249(13)00583-5. doi: 10.1016/j.jcyt.2013.06.002.
346. Influence of single nucleotide polymorphisms of cytokine genes on anti-HBs antibody production after hepatitis B vaccination in a Japanese young adult population. Yukimasa N, etal., J Med Invest. 2016;63(3-4):256-61. doi: 10.2152/jmi.63.256.
347. Cytokine profile in gingival crevicular fluid and plasma of patients with aggressive periodontitis. Zein Elabdeen HR, etal., Acta Odontol Scand. 2017 Nov;75(8):616-622. doi: 10.1080/00016357.2017.1372623. Epub 2017 Sep 3.
348. Splenectomy protects experimental rats from cerebral damage after stroke due to anti-inflammatory effects. Zhang BJ, etal., Chin Med J (Engl). 2013 Jun;126(12):2354-60.
349. Exosome-mediated targeted delivery of miR-210 for angiogenic therapy after cerebral ischemia in mice. Zhang H, etal., J Nanobiotechnology. 2019 Feb 19;17(1):29. doi: 10.1186/s12951-019-0461-7.
350. Study on the T-helper cell 1/2 cytokine profile in blister fluid of patients with herpes zoster and its clinical significance. Zhang M, etal., J Dermatol. 2011 Dec;38(12):1158-62. doi: 10.1111/j.1346-8138.2011.01289.x. Epub 2011 Sep 29.
351. Anti-inflammatory and immunomodulatory mechanisms of mesenchymal stem cell transplantation in experimental traumatic brain injury. Zhang R, etal., J Neuroinflammation. 2013 Aug 23;10(1):106. doi: 10.1186/1742-2094-10-106.
352. Mesenchymal stem cells ameliorate experimental autoimmune uveoretinitis by comprehensive modulation of systemic autoimmunity. Zhang X, etal., Invest Ophthalmol Vis Sci. 2011 May 16;52(6):3143-52. doi: 10.1167/iovs.10-6334.
353. Total Glucosides of Peony Attenuates 2,4,6-Trinitrobenzene Sulfonic Acid/Ethanol-Induced Colitis in Rats Through Adjustment of Th1/Th2 Cytokines Polarization. Zhang Y, etal., Cell Biochem Biophys. 2013 Jun 15.
354. IL-10-592 polymorphism is associated with IL-10 expression and severity of enterovirus 71 infection in chinese children. Zhao N, etal., J Clin Virol. 2017 Oct;95:42-46. doi: 10.1016/j.jcv.2017.08.005. Epub 2017 Aug 19.
355. [A study of the role of heme oxygenase-1 expression in ventilator induced lung injury and its mechanism in rats.] Zhao WJ and Hu WW, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 Jul;22(7):410-3.
356. Genetic variations in inflammation-related genes and their influence on the susceptibility of pediatric acute lung injury in a Chinese population. Zhao X, etal., Gene. 2019 Mar 1;687:16-22. doi: 10.1016/j.gene.2018.11.009. Epub 2018 Nov 6.
357. [The comparison of CD4(+) CD25(+) Treg, IL-10 and TGF-beta from lymph and blood in bronchial asthmatic rat and the effect of dexamethasone on it] Zhao ZX, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010 Mar;26(3):238-41.
358. Interleukin-10 gene promoter polymorphisms in multiple myeloma. Zheng C, etal., Int J Cancer. 2001 May 20;95(3):184-8.
359. IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats. Zheng W, etal., Mol Pain. 2014 Jul 30;10:49. doi: 10.1186/1744-8069-10-49.
360. Experimental autoimmune hearing loss is exacerbated in IL-10-deficient mice and reversed by IL-10 gene transfer. Zhou B, etal., Gene Ther. 2012 Feb;19(2):228-35. doi: 10.1038/gt.2011.88. Epub 2011 Jun 23.
361. Novel genetic association of Wegener's granulomatosis with the interleukin 10 gene. Zhou Y, etal., J Rheumatol. 2002 Feb;29(2):317-20.
362. Effects of Pseudomonas aeruginosa mannose-sensitive hemagglutinin (PA-MSHA) pretreatment on septic rats. Zhu H, etal., Int Immunopharmacol. 2013 Sep 18. pii: S1567-5769(13)00351-2. doi: 10.1016/j.intimp.2013.09.006.
363. Interleukin-10 inhibits neuroinflammation-mediated apoptosis of ventral mesencephalic neurons via JAK-STAT3 pathway. Zhu Y, etal., Int Immunopharmacol. 2017 Sep;50:353-360. doi: 10.1016/j.intimp.2017.07.017. Epub 2017 Jul 25.
Additional References at PubMed
PMID:1280414   PMID:1847510   PMID:1940799   PMID:7749983   PMID:8228801   PMID:8312229   PMID:8499633   PMID:9184696   PMID:9463379   PMID:9847016   PMID:10443688   PMID:10545106  
PMID:10899905   PMID:10940872   PMID:10975994   PMID:11027433   PMID:11244051   PMID:11777537   PMID:11900340   PMID:11943322   PMID:12020953   PMID:12452830   PMID:12547408   PMID:12692173  
PMID:12707357   PMID:12842419   PMID:15086467   PMID:15147725   PMID:15187136   PMID:15220916   PMID:15240714   PMID:15251379   PMID:15309723   PMID:15385469   PMID:15793858   PMID:16002150  
PMID:16034134   PMID:16086233   PMID:16275384   PMID:16460340   PMID:16522370   PMID:16606666   PMID:16670641   PMID:16949315   PMID:16982608   PMID:17105443   PMID:17137799   PMID:17174526  
PMID:17278885   PMID:17336456   PMID:17449476   PMID:17505796   PMID:17517520   PMID:17679732   PMID:17875732   PMID:18223607   PMID:18270204   PMID:18305394   PMID:18323732   PMID:18383040  
PMID:18403456   PMID:18407603   PMID:18471351   PMID:18533891   PMID:18665051   PMID:18841529   PMID:19047410   PMID:19097804   PMID:19139201   PMID:19567204   PMID:19575707   PMID:19716366  
PMID:19901158   PMID:19948415   PMID:20045008   PMID:20193756   PMID:20420568   PMID:20625799   PMID:21072211   PMID:21081156   PMID:21129280   PMID:21323571   PMID:21498587   PMID:21564091  
PMID:21609717   PMID:21763399   PMID:21857966   PMID:21887889   PMID:22152812   PMID:22326966   PMID:22593113   PMID:22796213   PMID:23071313   PMID:23111552   PMID:23141143   PMID:23143062  
PMID:23178472   PMID:23185784   PMID:23388469   PMID:23426971   PMID:23765634   PMID:23892723   PMID:24114903   PMID:24463741   PMID:24527865   PMID:24656930   PMID:24706318   PMID:24865534  
PMID:25009084   PMID:25066760   PMID:25081109   PMID:25096025   PMID:25182413   PMID:25329858   PMID:25471580   PMID:25504316   PMID:25598450   PMID:25617163   PMID:25702530   PMID:25780042  
PMID:26059905   PMID:26235810   PMID:26475712   PMID:26492380   PMID:26591203   PMID:26808574   PMID:26849241   PMID:26866372   PMID:26962683   PMID:27016017   PMID:27317647   PMID:27363620  
PMID:27456198   PMID:27567557   PMID:27703278   PMID:28063948   PMID:28092075   PMID:28132924   PMID:28135825   PMID:28258441   PMID:28319508   PMID:28322445   PMID:28368329   PMID:28387444  
PMID:28686630   PMID:28925732   PMID:29197741   PMID:29568872   PMID:29924982   PMID:30227622   PMID:30229836   PMID:30243650   PMID:30316971   PMID:30511618   PMID:30539780   PMID:30541949  
PMID:31067702   PMID:31162801   PMID:31415765   PMID:31434608   PMID:31915015   PMID:32004977   PMID:32303238   PMID:33028080   PMID:33540122   PMID:33902989   PMID:34123712   PMID:34343596  
PMID:35196893   PMID:36555251   PMID:36737628   PMID:37062956   PMID:38048666   PMID:38169599   PMID:38194074  


Genomics

Comparative Map Data
Il10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81345,024,921 - 45,029,586 (+)NCBIGRCr8
mRatBN7.21342,472,625 - 42,477,308 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,472,839 - 42,477,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,079,495 - 45,083,368 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01346,367,625 - 46,371,502 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01343,631,889 - 43,635,783 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01347,738,933 - 47,743,392 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,824,594 - 52,828,560 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,953,900 - 43,957,766 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11343,967,906 - 43,972,374 (+)NCBI
Celera1342,821,569 - 42,825,416 (+)NCBICelera
Cytogenetic Map13q13NCBI
IL10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,767,602 - 206,772,494 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1206,767,602 - 206,774,541 (-)EnsemblGRCh38hg38GRCh38
GRCh371206,940,947 - 206,945,839 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361205,007,571 - 205,012,462 (-)NCBINCBI36Build 36hg18NCBI36
Build 341203,329,342 - 203,334,234NCBI
Celera1180,192,396 - 180,197,294 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,639,274 - 177,644,165 (-)NCBIHuRef
CHM1_11208,213,574 - 208,218,465 (-)NCBICHM1_1
T2T-CHM13v2.01206,031,803 - 206,036,695 (-)NCBIT2T-CHM13v2.0
Il10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,947,459 - 130,952,707 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,947,582 - 130,952,711 (+)EnsemblGRCm39 Ensembl
GRCm381131,019,845 - 131,024,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,019,845 - 131,024,974 (+)EnsemblGRCm38mm10GRCm38
MGSCv371132,916,422 - 132,921,547 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,847,393 - 132,852,516 (+)NCBIMGSCv36mm8
Celera1133,642,456 - 133,647,581 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map156.89NCBI
Il10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,307,664 - 42,312,779 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,307,789 - 42,312,255 (-)NCBIChiLan1.0ChiLan1.0
IL10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2142,602,021 - 42,609,622 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1142,567,540 - 42,575,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01182,369,234 - 182,374,207 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11186,648,289 - 186,653,155 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,648,289 - 186,653,371 (-)Ensemblpanpan1.1panPan2
IL10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,933,285 - 5,937,057 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,933,285 - 5,937,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,497,391 - 5,501,163 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,622,589 - 5,626,365 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,622,079 - 5,626,428 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,557,139 - 5,560,910 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,658,009 - 5,661,775 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,697,728 - 5,701,500 (-)NCBIUU_Cfam_GSD_1.0
Il10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,594,566 - 68,598,867 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,834,874 - 5,838,502 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365575,834,874 - 5,838,502 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,400,728 - 67,405,378 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,400,727 - 67,405,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,757,707 - 73,762,925 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,590,389 - 22,595,877 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,590,962 - 22,594,836 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,288,754 - 23,293,715 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,687,176 - 4,691,732 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,687,249 - 4,691,658 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il10
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:377
Count of miRNA genes:195
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000006246
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat

Markers in Region
Il10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,472,894 - 42,474,370 (+)MAPPERmRatBN7.2
Rnor_6.01347,739,541 - 47,741,015NCBIRnor6.0
Rnor_5.01352,824,709 - 52,826,183UniSTSRnor5.0
Celera1342,821,584 - 42,823,038UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 3 20 12 18 12 5 3
Below cutoff 11 31 24 1 24 2 3 3 24 23 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006246   ⟹   ENSRNOP00000006246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,472,839 - 42,477,313 (+)Ensembl
Rnor_6.0 Ensembl1347,739,526 - 47,743,392 (+)Ensembl
RefSeq Acc Id: NM_012854   ⟹   NP_036986
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,025,154 - 45,029,020 (+)NCBI
mRatBN7.21342,472,880 - 42,476,748 (+)NCBI
Rnor_6.01347,739,526 - 47,743,392 (+)NCBI
Rnor_5.01352,824,594 - 52,828,560 (+)NCBI
RGSC_v3.41343,953,900 - 43,957,766 (+)RGD
Celera1342,821,569 - 42,825,416 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249712   ⟹   XP_006249774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,024,933 - 45,029,586 (+)NCBI
mRatBN7.21342,472,628 - 42,477,308 (+)NCBI
Rnor_6.01347,738,933 - 47,742,783 (+)NCBI
Rnor_5.01352,824,594 - 52,828,560 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769426   ⟹   XP_008767648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81345,024,921 - 45,029,586 (+)NCBI
mRatBN7.21342,472,625 - 42,477,308 (+)NCBI
Rnor_6.01347,738,933 - 47,741,583 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_036986   ⟸   NM_012854
- Peptide Label: precursor
- UniProtKB: Q63263 (UniProtKB/Swiss-Prot),   P29456 (UniProtKB/Swiss-Prot),   A0A7R8C3K4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249774   ⟸   XM_006249712
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008767648   ⟸   XM_008769426
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000006246   ⟸   ENSRNOT00000006246

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29456-F1-model_v2 AlphaFold P29456 1-178 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698790
Promoter ID:EPDNEW_R9315
Type:single initiation site
Name:Il10_1
Description:interleukin 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01347,739,459 - 47,739,519EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2886 AgrOrtholog
BioCyc Gene G2FUF-18358 BioCyc
Ensembl Genes ENSRNOG00000004647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021506 UniProtKB/Swiss-Prot
  ENSRNOG00060014812 UniProtKB/Swiss-Prot
  ENSRNOG00065020717 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006246 ENTREZGENE
  ENSRNOT00000006246.6 UniProtKB/Swiss-Prot
  ENSRNOT00055036739 UniProtKB/Swiss-Prot
  ENSRNOT00060025317 UniProtKB/Swiss-Prot
  ENSRNOT00065035115 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10/19/20/22/24/26_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-10_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25325 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25325 ENTREZGENE
PANTHER INTERLEUKIN-10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERLEUKIN-19-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB IL10 RGD
PhenoGen Il10 PhenoGen
PRINTS INTRLEUKIN10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE INTERLEUKIN_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004647 RatGTEx
  ENSRNOG00055021506 RatGTEx
  ENSRNOG00060014812 RatGTEx
  ENSRNOG00065020717 RatGTEx
SMART IL10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC224831
UniProt A0A7R8C3K4 ENTREZGENE, UniProtKB/TrEMBL
  IL10_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63263 ENTREZGENE
UniProt Secondary Q63263 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Il10  Interleukin 10      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen and macrophages 729048
gene_process may have a role in inflammation 729048