Gene:	Il10 ( Rattus norvegicus ) interleukin 10
Description:	an anti-inflammatory cytokine involved in the inhibition of cytokine synthesis, the negative regulation of apoptosis, and the regulation of the sensory perception of pain; associated with many diseases
Synonyms:	IL10X;
ArrayIDs:	6434848; A_43_P11588; 6045912; 1387711_at; GE1254757; A_44_P384213; X60675_at; 5842251; 6112545; 5685977; 6417734; L02926_s_at; 6488129;  (details...)
Gene Type:	protein-coding
Additional Data
Homologs
Homo sapiens: IL10     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Il10     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Il10 genome assembly 3.1 13 43967906 - 43972374     Rat Celera Assembly 13 42821528 - 42825982     RGSC genome assembly v3.4 13 43953859 - 43958332     Cytogenetic 13 q13 Mus musculus Il10 Mouse genome assembly build 36.1 1 132916424 - 132921547     Cytogenetic 1 1 E4 Homo sapiens IL10 human genome assembly 1 203329342 - 203334234     Human genome assembly build 36.2 1 205007571 - 205012462     Cytogenetic 1 q31-q32   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology protein binding,  interleukin-10 receptor binding,  cytokine activity (details...)
Biological Process	Note Reference may have a role in inflammation 729048 Gene Ontology response to glucocorticoid stimulus,  positive regulation of transcription factor activity,  positive regulation of cytokine secretion ...  (details...)
Cellular Component	Gene Ontology extracellular space,  extracellular region (details...)
Disease	Ontology Myocarditis,  Diabetic Retinopathy,  Sjogren's Syndrome ...  (details...)
Expression	Note Reference expressed in spleen and macrophages 729048
Pathway	Ontology Interleukin-10 signaling pathway (details...)
External Links
Databases	DATABASE ID SOURCE SMART: IL10 IPI PROSITE: INTERLEUKIN_10 IPI UNIPARC: UPI000012D477 IPI KEGG Report: rno:25325 ENTREZGENE HomoloGene Group ID: 478 ENTREZGENE Germonline: 2886 Pfam: IL10 IPI KEGG Pathway: 05310 ENTREZGENE KEGG Pathway: 05320 ENTREZGENE KEGG Pathway: 04060 ENTREZGENE KEGG Pathway: 05330 ENTREZGENE KEGG Pathway: 04630 ENTREZGENE KEGG Pathway: 04660 ENTREZGENE KEGG Pathway: 05322 ENTREZGENE InterPro: Interleukin_10. IPI InterPro: Interleukin-10_CS. IPI InterPro: Interleukin-10/19/20/24. IPI InterPro: IL-10_add_helix. IPI InterPro: 4_helix_cytokine_core. IPI InterPro: 4_helix_cytokine-like_core. IPI Ensembl Protein: ENSRNOP00000006246 IPI IPI: IPI00326111 IPI Gene3D-CATH: 4_helix_cytokine_core IPI Gene3D-CATH: IL-10_add_helix IPI Entrez Gene: Il10 ENTREZGENE Ensembl Genes: ENSRNOG00000004647 IPI TIGR: TC224831 UniProt: IL10_RAT IPI RatMap: 41210 ENTREZGENE Superfamily-SCOP: 4_helix_cytokine IPI PANTHER: Interleukin_10 IPI PRINTS: INTRLEUKIN10. IPI
Sequences	Nucleotide: X60675 Get FASTA Search GEO Profiles Nucleotide: L02926 Get FASTA Search GEO Profiles Nucleotide: CH473958 Get FASTA Search GEO Profiles Nucleotide: NM_012854 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: P29456 Get FASTA Protein: CAA43090 Get FASTA Protein: AAA41425 Get FASTA Protein: EDM09836 Get FASTA Protein: NP_036986 Get FASTA (View all 5 Protein Accessions)
Clusters	UniGene: 9868
References
Curated References	71 references in RGD related to Il10
Other References	74 other references at PubMed related to Il10
Database Information
RGD ID	2886
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 10-JUN-02: Il10 Interleukin 10 APPROVED Symbol and Name status set to approved 70586