RGD Reference Report - Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis. - Rat Genome Database

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Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis.

Authors: Abu El-Asrar, AM  Struyf, S  Kangave, D  Al-Obeidan, SA  Opdenakker, G  Geboes, K  Van Damme, J 
Citation: Abu El-Asrar AM, etal., Cytokine. 2012 Aug;59(2):377-81. doi: 10.1016/j.cyto.2012.04.030. Epub 2012 May 12.
RGD ID: 7364832
Pubmed: PMID:22583692   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2012.04.030   (Journal Full-text)

Aqueous humor (AH) samples from 14 patients with presumed tuberculous uveitis (PTU), and 30 control patients were assayed for the proinflammatory cytokines interleukin IL-4, IL-12, IL-15, IL-17, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha, the immunosuppressive cytokine IL-10, and the chemokines GRO-alpha/CXCL1, IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and SDF-1/CXCL12 with the use of a multiplex assay. Among cytokines, IL-4 and IL-12 were not detected. IL-15, IL-17, IFN-gamma, TNF-alpha and IL-10 levels in AH were significantly higher in patients than in controls (p<0.001; p=0.004; p<0.001; p<0.001; p<0.001, respectively). Among chemokines, SDF-1 levels did not differ significantly between patients and controls, whereas GRO-alpha, IL-8, MIG and IP-10 levels were significantly higher in patients than in controls (p=0.001; p<0.001; p<0.001; p<0.001, respectively). Mean GRO-alpha levels in AH of PTU patients were 6-fold higher than IL-8 levels and mean IP-10 levels were 15-fold higher than MIG levels. Clinical disease activity correlated significantly with the levels of IL-15, IFN-gamma, TNF-alpha and IP-10. Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-gamma, IL-8, MIG and IP-10. These data suggest that both T helper (Th) Th(1) and Th(17) cells are involved in PTU and that the cytokine profile is polarized toward a Th(1) response. GRO-alpha and IP-10 might be involved in neutrophil and activated T lymphocyte chemoattraction in PTU, respectively.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ocular tuberculosis  IEP 7364832protein:increased expression:aqueous humorRGD 
ocular tuberculosis  ISOIL10 (Homo sapiens)7364832; 7364832protein:increased expression:aqueous humorRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information