RGD Reference Report - Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model. - Rat Genome Database

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Interleukin-10 is an essential modulator of mucoid metaplasia in a mouse otitis media model.

Authors: Tsuchiya, K  Komori, M  Zheng, QY  Ferrieri, P  Lin, J 
Citation: Tsuchiya K, etal., Ann Otol Rhinol Laryngol. 2008 Aug;117(8):630-6.
RGD ID: 7365029
Pubmed: PMID:18771082   (View Abstract at PubMed)
PMCID: PMC2692729   (View Article at PubMed Central)

OBJECTIVES: Inflammatory cytokines are involved in the development of mucous cell metaplasia and hyperplasia (MCM) in otitis media (OM). However, which cytokines play an essential role in the MCM of OM is not clear at the moment. METHODS: In this study, we hypothesized that interleukin-10 (IL-10) played an indispensable role in the MCM of bacterial OM, and we used IL-10 knockout mice to test this hypothesis. RESULTS: In wild-type mice, both Streptococcus pneumoniae and Haemophilus influenzae triggered the development of MCM in the middle ear mucosa. In IL-10 knockout mice, the number of goblet cells and mucin-producing cells in the middle ear was significantly reduced after bacterial middle ear infection compared with that in wild-type mice. CONCLUSIONS: We conclude that IL-10 plays an essential role in the MCM of bacterial OM. Interleukin-10 is a potential target for the treatment of MCM in OM.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
otitis media  ISOIl10 (Mus musculus)7365029; 7365029 RGD 
otitis media  IMP 7365029 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information