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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10increases expressionEXP 6480464CTDEstradiol results in increased expression of IL10 mRNAPMID:29425760
Il10multiple interactionsEXP 6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of IL10 mRNA; Estradiol promotes the reaction [Excitatory Amino Acid Agonists results in increased expression of IL10 mRNA]PMID:29425760 PMID:32741896
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTDEstradiol inhibits the reaction [[Galactose co-treated with Aluminum Chloride] results in decreased expression of IL10 protein]PMID:35537655
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTD[Progesterone co-treated with Estradiol] promotes the reaction [Vaccines, Virus-Like Particle results in increased expression of IL10 protein]; Estradiol promotes the reaction [Vaccines, Virus-Like Particle results in increased expression of IL10 protein]PMID:20130130
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