INTERLEUKIN-10 SIGNALING PATHWAY (PW:0000515)

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Description

Interleukin-10 (Il-10) is a prominent member of the interleukin 10 family of cytokines which also includes interleukin 28A, 28B and 29 known as interferon type III or lambda. In addition to the mammalian proteins, several viral homologues are also known. The many biological actions of Il-10 impinge upon the release of immune mediators and antigen presentation with an overall anti-inflammatory effect; interestingly it is Il-10 and not the other members of the family that appear to promote such ef

Pathway Diagram:

Ariadne Genomics Inc. P-Tyr1 P-Tyr2 Jak1 Stat3 Jak-Stat signaling pathway Stat1 Il10ra ---- Stat1 Il10 P-Tyr2 ---- Stat3 Il10ra Il10 ---- Il10ra Il10rb --+> Tyk2 Tyk2 Il10ra --+> Jak1 Tyk2 ---> Il10ra Il10ra ---- Jak1 Il10 --+> Stat3 Jak1 ---> Il10ra Il10 --+> Stat1 Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---> Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---- Il10rb Il10rb Il10rb ---- Tyk2
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Genes in Pathway:

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Interleukin-10 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:1580494
RGD:2311043
RGD:5688379
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:2311043
RGD:5688379
G Il10rb interleukin 10 receptor subunit beta JBrowse link 11 31,560,301 31,582,457 RGD:5688379
G Jak1 Janus kinase 1 JBrowse link 5 119,982,503 120,091,452 RGD:5688379
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:5688379
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:2311043
RGD:5688379
G Tyk2 tyrosine kinase 2 JBrowse link 8 22,118,224 22,149,807 RGD:5688379

Pathway Gene Annotations

Disease Annotations Associated with Genes in the Interleukin-10 signaling pathway
Disease TermsGene Symbols
Acute Kidney InjuryIl10
Acute Lung InjuryIl10
AdenocarcinomaStat3
Airway ObstructionIl10
Alveolar Bone LossIl10
Alzheimer DiseaseIl10 , Stat3
AnemiaIl10
Anemia, Hemolytic, AutoimmuneIl10
Anemia, Sickle CellIl10
AngiomyolipomaStat1 , Stat3
Anti-Glomerular Basement Membrane DiseaseIl10
AppendicitisIl10
ArteriosclerosisIl10
Arthritis, ExperimentalIl10 , Stat1 , Stat3
Arthritis, JuvenileStat3
Arthritis, PsoriaticStat3
Arthritis, RheumatoidIl10 , Stat1 , Stat3 , Tyk2
AsthenopiaIl10
AsthmaIl10
AtherosclerosisStat3
AtrophyStat3
Autistic DisorderIl10 , Stat3
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1Stat3
Autoimmune DiseasesStat3
Bacterial InfectionsIl10
Behcet SyndromeIl10 , Stat3
Brain InjuriesIl10 , Stat1 , Stat3
Brain IschemiaIl10rb , Stat3
Breast NeoplasmsStat1 , Stat3
Bronchial HyperreactivityIl10
Bronchitis, ChronicIl10
BurnsIl10
Candidiasis, Chronic MucocutaneousStat1
Candidiasis, Familial, 7Stat1
CarcinomaStat3
Carcinoma, BronchogenicIl10
Carcinoma, HepatocellularIl10 , Stat1
Carcinoma, Non-Small-Cell LungIl10 , Stat3
Carcinoma, Renal CellStat3
Carcinoma, Squamous CellStat3
Carcinoma, Squamous Cell of Head and NeckStat3
CardiomegalyStat3
CardiomyopathiesStat3
Cardiomyopathy, DilatedIl10
Carotid Artery DiseasesIl10
Carotid StenosisIl10
Cell Transformation, NeoplasticStat3
Cervical Intraepithelial NeoplasiaStat3
Chagas CardiomyopathyIl10
Choroid DiseasesIl10
Choroidal NeovascularizationIl10 , Stat3
Churg-Strauss SyndromeStat3
Cocaine-Related DisordersTyk2
ColitisIl10
Colitis, ExperimentalIl10
Colonic NeoplasmsStat3
Common ColdIl10
Conjunctivitis, AllergicIl10
Copper-Overload CirrhosisStat3
Coronary Artery DiseaseIl10
Crohn DiseaseIl10 , Stat3 , Tyk2
Cytomegalovirus InfectionsStat1
Cytomegalovirus RetinitisIl10
Depression, PostpartumIl10
Dermatitis, Allergic ContactIl10
Dermatitis, AtopicIl10
Dermatitis, IrritantStat3
Diabetes MellitusIl10
Diabetes Mellitus, ExperimentalIl10 , Stat1 , Stat3
Diabetes Mellitus, Type 1Il10 , Stat3
Diabetes Mellitus, Type 2Il10 , Stat3
Diabetes, GestationalIl10
Diabetic CardiomyopathiesIl10
Diabetic NephropathiesIl10 , Stat3
Diabetic RetinopathyIl10
Disease Models, AnimalStat3
Disease ProgressionStat1
Disseminated Intravascular CoagulationIl10
Drug HypersensitivityIl10
Dry Eye SyndromesIl10
Duodenal UlcerStat3
Eales DiseaseIl10
Encephalomyelitis, Autoimmune, ExperimentalIl10 , Il10ra , Stat1 , Stat3
Endometrial NeoplasmsIl10 , Stat3
EndometriosisIl10
EndotoxemiaIl10
EntamoebiasisIl10
EnterocolitisIl10
Enterocolitis, NecrotizingIl10 , Il10rb
Epidermal HyperplasiaStat3
Eye BurnsIl10
Fanconi AnemiaIl10
Fatty LiverIl10
Femoral FracturesIl10
FeverStat3
FibrosisStat3
Gallbladder NeoplasmsIl10
Genetic Diseases, InbornJak1
Genetic Predisposition to DiseaseIl10
Glaucoma, Open-AngleIl10
GliomaIl10
GlomerulonephritisIl10
Glucosephosphate Dehydrogenase DeficiencyIl10
Graft vs Host DiseaseIl10 , Il10rb
Granuloma, PyogenicStat3
Granulomatosis with PolyangiitisIl10
Graves DiseaseIl10
Graves OphthalmopathyIl10
Hearing LossIl10 , Stat1
Heart DiseasesStat3
Heart FailureIl10
Heat StrokeIl10
HemangiosarcomaStat3
Hemophilia AIl10
Heparin-induced ThrombocytopeniaIl10
Hepatitis BIl10rb
Hepatitis CIl10
Hepatitis C, ChronicStat3
Hepatitis, AutoimmuneIl10
Hepatitis, ChronicStat3
Hepatolenticular DegenerationIl10
Hernias, Diaphragmatic, CongenitalStat3
Herpes ZosterIl10
HIV InfectionsIl10
Hodgkin DiseaseIl10
Hyper-Ige Recurrent Infection Syndrome, Autosomal DominantStat3
HyperalgesiaIl10 , Stat3
Hypersensitivity, ImmediateIl10
HypertensionIl10
Hypertension, PulmonaryIl10
HyperthyroidismIl10
HyperuricemiaStat3
HypothyroidismIl10
Idiopathic Pulmonary FibrosisStat3
IMMUNODEFICIENCY 31AStat1
Infarction, Middle Cerebral ArteryStat3
InflammationIl10 , Stat3
Inflammatory Bowel Disease 11Il10 , Stat3
Inflammatory Bowel Disease 25, Autosomal RecessiveIl10rb
Inflammatory Bowel Disease 28, Autosomal RecessiveIl10ra , Il10rb
Inflammatory Bowel DiseasesIl10 , Il10ra , Il10rb
Influenza, HumanIl10 , Stat1
Intestinal ObstructionIl10
Irritable Bowel SyndromeIl10
Ischemic Attack, TransientIl10 , Stat3
Job SyndromeStat3
Keratitis, HerpeticIl10
Kidney Reperfusion InjuryIl10
LeishmaniasisIl10
Leishmaniasis, CutaneousIl10
Leishmaniasis, VisceralIl10 , Il10ra
Leukemia, Large Granular LymphocyticStat3
Leukemia, Lymphocytic, Chronic, B-CellIl10
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveIl10
Leukemia, Myeloid, AcuteIl10 , Jak1 , Stat3
Leukemia, T-CellStat3
Leukemia-Lymphoma, Adult T-CellIl10 , Stat3
Liver CirrhosisStat1 , Stat3
Liver Cirrhosis, BiliaryTyk2
Liver Cirrhosis, ExperimentalIl10
Liver InjuryStat3
Liver NeoplasmsIl10 , Stat3
Liver Reperfusion InjuryIl10
Lung DiseasesIl10
Lung NeoplasmsIl10
Lupus Erythematosus, SystemicIl10
LymphangioleiomyomatosisStat1 , Stat3
Lymphatic MetastasisStat3
Lymphoblastic Leukemia, Acute, with Lymphomatous FeaturesJak1
LymphomaIl10
Lymphoma, Large-Cell, AnaplasticStat3
Lymphoma, T-CellStat3
Lymphoproliferative DisordersStat3
Mammary Neoplasms, AnimalStat3
Mammary Neoplasms, ExperimentalIl10 , Stat1 , Stat3
MedulloblastomaStat3
Melanoma, Cutaneous MalignantStat3
Memory DisordersStat3
Mitral Valve StenosisIl10
MucositisIl10
Multiple MyelomaIl10
Multiple Organ FailureIl10
Multiple SclerosisTyk2
Murine Acquired Immunodeficiency SyndromeIl10
Mycobacterial and Viral Infections, Susceptibility To, Autosomal RecessiveStat1
Mycobacterium InfectionsStat1
Mycobacterium Infections, NontuberculousStat1 , Tyk2
Myocardial InfarctionIl10
Myocardial Reperfusion InjuryIl10 , Stat1 , Stat3
MyocarditisIl10
Nasal PolypsIl10 , Stat3
Neoplasm MetastasisIl10 , Stat3
NeuralgiaIl10
Neurotoxicity SyndromesIl10
Niemann-Pick Disease, Type CStat3
Non-alcoholic Fatty Liver DiseaseStat3
ObesityIl10 , Stat3
Otitis MediaIl10
Ovarian NeoplasmsIl10 , Stat3
Oxygen-Induced RetinopathyStat3
Pancreatic NeoplasmsIl10 , Stat3
PancreatitisIl10
Pancreatitis, Experimental, Acute Il10
PanuveitisIl10
Paranoid DisordersTyk2
Pericardial EffusionIl10
PeriodontitisIl10
PlasmacytomaIl10
PleurisyIl10
PneumoniaIl10
Pneumonia, BacterialStat3
Pneumonia, StaphylococcalIl10
Pneumonia, ViralIl10
Polycythemia VeraJak1
Precancerous ConditionsStat3
Precursor B-Cell Lymphoblastic Leukemia-LymphomaStat3
Precursor Cell Lymphoblastic Leukemia-LymphomaIl10
Precursor T-Cell Lymphoblastic Leukemia-LymphomaStat1 , Tyk2
Pregnancy-associated MalariaIl10
Pressure UlcerIl10
Primary Graft DysfunctionIl10
Prostatic NeoplasmsIl10 , Stat1 , Stat3
ProstatitisIl10
Pseudomonas Aeruginosa KeratitisIl10
PsoriasisIl10 , Stat3 , Tyk2
Pulmonary EosinophiliaIl10
Pulmonary FibrosisStat1 , Stat3
Purpura, Thrombocytopenic, IdiopathicIl10
Radiation Injuries, ExperimentalIl10
Reoviridae InfectionsStat1
Reperfusion InjuryIl10 , Stat1 , Stat3
Respiratory Distress Syndrome, AdultIl10
Respiratory HypersensitivityIl10
Respiratory Syncytial Virus InfectionsIl10
Retina Reperfusion InjuryStat3
Retinal Artery OcclusionIl10
Retinal DiseasesIl10
Retinopathy of PrematurityIl10
Retroviridae InfectionsIl10
Rheumatic Heart DiseaseIl10
Rhinitis, AllergicIl10
Rhinitis, Allergic, SeasonalIl10
RhinosinusitisIl10
SchizophreniaIl10
Sciatic NeuropathyIl10
Scleroderma, DiffuseIl10
ScrapieStat1 , Stat3
SepsisIl10 , Stat1 , Stat3
Sepsis-Associated EncephalopathyStat3
Shock, HemorrhagicIl10
Shock, SepticIl10
Shwartzman PhenomenonIl10
Sjogren's SyndromeIl10
Skin DiseasesIl10
Skin NeoplasmsStat3
Sleep Apnea, ObstructiveIl10
Smith-Magenis SyndromeStat3
SplenomegalyIl10
Squamous Cell Carcinoma of the TongueIl10
Staphylococcal InfectionsIl10
Stomach NeoplasmsStat3
StrokeIl10
Subarachnoid HemorrhageStat3
ThrombocytopeniaIl10
ThrombosisIl10
ThyrotoxicosisIl10
Tongue NeoplasmsStat3
Toxoplasma ChorioretinitisIl10
Toxoplasmosis, OcularIl10
TrachomaIl10
Transplant RejectionIl10
Trauma, Nervous SystemStat1
TrichinellosisIl10
Tuberculosis, OcularIl10
Tyrosine Kinase 2 DeficiencyTyk2
Uterine Cervical NeoplasmsIl10 , Stat3
UveitisIl10
Uveitis, Autoimmune, ExperimentalIl10 , Stat3
Uveitis, IntermediateIl10
Uveoretinitis, Autoimmune, ExperimentalIl10 , Stat3
VasculitisIl10
Venous ThrombosisIl10
Ventilator-Induced Lung InjuryIl10
Waldenstrom MacroglobulinemiaIl10
Weight LossIl10
Wilms TumorStat1 , Stat3
Wounds and InjuriesIl10
Wounds, PenetratingIl10
Pathway Annotations Associated with Genes in the Interleukin-10 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayStat3
allograft rejection pathwayIl10
angiotensin II signaling pathway via AT1 receptorTyk2
asthma disease pathwayIl10
autoimmune thyroid disease pathwayIl10
ceramide signaling pathwayJak1 , Stat1 , Stat3
chemokine mediated signaling pathwayStat1 , Stat3
cytokine mediated signaling pathwayIl10 , Il10ra , Il10rb
Entamoeba histolyca infection pathwayIl10
epidermal growth factor/neuregulin signaling pathwayStat1 , Stat3
erythropoietin signaling pathwayStat1
fibroblast growth factor signaling pathwayStat1
granulocyte-macrophage colony-stimulating factor signaling pathwayStat1 , Stat3
hepatitis C virus infection pathwayJak1 , Stat1 , Stat3
influenza A virus infection pathwayJak1 , Stat1
Interleukin-10 signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
interleukin-12 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-2 signaling pathwayJak1 , Stat1 , Stat3
interleukin-23 signaling pathwayStat1 , Stat3 , Tyk2
interleukin-27 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
interleukin-4 signaling pathwayIl10 , Jak1
interleukin-6 signaling pathwayJak1 , Stat1 , Stat3 , Tyk2
Jak-Stat signaling pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3 , Tyk2
Leishmania infection pathwayIl10 , Jak1 , Stat1
leptin system pathwayStat3
measles infection pathwayJak1 , Stat1 , Stat3
Mycobacterium tuberculosis infection pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1
Non-Stat, Jak dependent pathwayJak1 , Tyk2
pancreatic cancer pathwayJak1 , Stat1 , Stat3
Plasmodium infection pathwayIl10
platelet-derived growth factor signaling pathwayJak1 , Stat1 , Stat3
Staphylococcus aureus infection pathwayIl10
systemic lupus erythematosus pathwayIl10
T cell receptor signaling pathwayIl10
Toll-like receptor signaling pathwayStat1
Toxoplasma gondii infection pathwayIl10 , Il10ra , Il10rb , Jak1 , Stat1 , Stat3
Trypanosoma brucei infection pathwayIl10
Trypanosoma cruzi infection pathwayIl10
tumor necrosis factor mediated signaling pathwayStat1
type II interferon signaling pathwayJak1 , Stat1 , Stat3

References Associated with the Interleukin-10 signaling pathway:

Ontology Path Diagram:

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