RGD Reference Report - Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis. - Rat Genome Database

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Frequency of polymorphisms of signal peptide of TGF-beta1 and -1082G/A SNP at the promoter region of Il-10 gene in patients with carotid stenosis.

Authors: Crivello, A  Giacalone, A  Scola, L  Forte, GI  Nuzzo, D  Giacconi, R  Cipriano, C  Candore, G  Mocchegiani, E  Colonna-Romano, G  Lio, D  Caruso, C 
Citation: Crivello A, etal., Ann N Y Acad Sci. 2006 May;1067:288-93.
RGD ID: 1598483
Pubmed: PMID:16804000   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1354.038   (Journal Full-text)

The role of inflammation in atherosclerosis is well recognized. We have evaluated the allele frequencies of the +869T/C and +915G/C polymorphisms (SNPs) at the TGF-beta1 gene and -1082G/A SNP at IL-10 promoter sequence, two well-known immunosuppressive and anti-inflammatory cytokines, in patients with carotid stenosis. Our data suggest a lack of association between these SNPs and the susceptibility to atherosclerosis although other reports have demonstrated this association. These results may be due to the pleiotropic effects of the cytokines and/or differences in haplotype combination that should be investigated to elucidate the role of TGF-beta1 and IL-10 polymorphisms in atherosclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
carotid stenosis no_associationIAGP 1598483 RGD 
carotid stenosis no_associationISOIL10 (Homo sapiens)1598483; 1598483 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information