RGD Reference Report - Analysis of tear cytokines and clinical correlations in Sjogren syndrome dry eye patients and non-Sjogren syndrome dry eye patients. - Rat Genome Database

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Analysis of tear cytokines and clinical correlations in Sjogren syndrome dry eye patients and non-Sjogren syndrome dry eye patients.

Authors: Lee, SY  Han, SJ  Nam, SM  Yoon, SC  Ahn, JM  Kim, TI  Kim, EK  Seo, KY 
Citation: Lee SY, etal., Am J Ophthalmol. 2013 Aug;156(2):247-253.e1. doi: 10.1016/j.ajo.2013.04.003. Epub 2013 Jun 7.
RGD ID: 7364807
Pubmed: PMID:23752063   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ajo.2013.04.003   (Journal Full-text)

PURPOSE: To compare concentrations of tear cytokines in 3 groups composed of Sjogren syndrome (SS) dry eye, non-Sjogren syndrome (non-SS) dry eye, and normal subjects. Correlations between ocular surface parameters and tear cytokines were also investigated. DESIGN: Prospective cross-sectional study. METHODS: SS dry eye patients (n = 24; 40 eyes) were diagnosed with primary SS according to the criteria set by the American-European Consensus Group. Non-SS dry eye patients (n = 25; 40 eyes) and normal subjects (n = 21; 35 eyes) were also enrolled. Tear concentrations of interleukin (IL)-17, IL-6, IL-10, IL-4, IL-2, interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF-alpha) were measured by a multiplex immunobead assay. Ocular Surface Disease Index (OSDI), tear film breakup time (TBUT), Schirmer I test, and fluorescein staining scores were obtained from dry eye patients. RESULTS: All cytokine levels except for IL-2 were highest in the SS group, followed by non-SS dry eye group and control subjects. Concentrations of IL-17, TNF-alpha, and IL-6 were significantly different among the 3 groups (IL-17: SS > control P < .001, non-SS > control P = .042, SS > non-SS P < .001; TNF-alpha: SS > control P = .006, non-SS > control P = .034, SS > non-SS P = .029; IL-6: SS > control P = .002, non-SS > control P = .032, SS > non-SS P = .002). IL-17 was significantly correlated with TBUT (R = -0.22, P = .012) and Schirmer I test (R = -0.36, P = .027) scores in the SS group. IL-6 was significantly correlated only with TBUT (R = -0.38, P = .02) in the non-SS group. CONCLUSIONS: Differences in tear cytokine levels and correlation patterns between SS dry eye and non-SS dry eye patients suggest the involvement of different inflammatory processes as causes of dry eye syndrome.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dry eye syndrome  IEP 7364807associated with Sjogren's Syndrome and protein:increased expression:tearRGD 
dry eye syndrome  ISOIL10 (Homo sapiens)7364807; 7364807associated with Sjogren's Syndrome and protein:increased expression:tearRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information