RGD Reference Report - Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis. - Rat Genome Database

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Elevated serum levels of interleukin 4 (IL-4), IL-10, and IL-13 in patients with systemic sclerosis.

Authors: Hasegawa, M  Fujimoto, M  Kikuchi, K  Takehara, K 
Citation: Hasegawa M, etal., J Rheumatol. 1997 Feb;24(2):328-32.
RGD ID: 5684371
Pubmed: PMID:9034992   (View Abstract at PubMed)

OBJECTIVE: To determine whether serum interleukin 4 (IL-4), IL-10, and IL-13 levels in patients with systemic sclerosis (SSc) are elevated and whether they correlate with the clinical or serologic features of this disease. METHODS: Serum samples from patients with limited cutaneous SSc (ISSc) (n = 45), diffuse cutaneous SSc (dSSc) (n = 28), and control subjects (n = 30) were examined by ELISA. RESULTS: Serum IL-4 and IL-13 levels were significantly higher in patients with ISSc and dSSc than in the controls. Serum IL-10 levels were significantly higher in the patients with dSSc compared with controls. Elevated IL-10 levels were detected frequently in patients with arthralgia. Serum IL-13 levels correlated with erythrocyte sedimentation rates and C-reactive protein levels in patients. CONCLUSION: We suggest that IL-4, IL-10, and IL-13 may be some of the cytokines that contribute to the disease process, and that IL-13 may be a serologic indicator of systemic inflammation in patients with SSc.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diffuse scleroderma  IEP 5684371protein:increased expression:serumRGD 
diffuse scleroderma  ISOIL10 (Homo sapiens)5684371; 5684371protein:increased expression:serumRGD 
systemic scleroderma  IEP 5684371; 5684371protein:increased expression:serumRGD 
systemic scleroderma  ISOIL13 (Homo sapiens)5684371; 5684371protein:increased expression:serumRGD 
systemic scleroderma  ISOIL4 (Homo sapiens)5684371; 5684371protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)
Il13  (interleukin 13)
Il4  (interleukin 4)

Genes (Mus musculus)
Il10  (interleukin 10)
Il13  (interleukin 13)
Il4  (interleukin 4)

Genes (Homo sapiens)
IL10  (interleukin 10)
IL13  (interleukin 13)
IL4  (interleukin 4)


Additional Information