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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases abundanceEXP 152995414RGD2,4,6-trinitrobenzenesulfonic acid decreases abundance of IL-10 protein in rat colon 
Il10decreases expressionEXP 6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of IL10; Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA; Trinitrobenzenesulfonic Acid results in decreased expression of IL10 proteinPMID:15604057 PMID:16867261 PMID:24316276 PMID:25727887 PMID:33412153
Il10decreases secretionEXP 6480464CTDTrinitrobenzenesulfonic Acid results in decreased secretion of IL10 proteinPMID:25729217
Il10increases expressionEXP 6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of IL10 proteinPMID:24831514 PMID:30365937 PMID:35290143
Il10multiple interactionsEXP 6480464CTD[iberogast analog co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 mRNA; [iberogast co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 mRNA; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10]; Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; oxymatrine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]PMID:15604057 PMID:16867261 PMID:19196500 PMID:24316276 PMID:24831514 PMID:25727887 PMID:30365937 PMID:33412153 PMID:35290143
Il10decreases expressionISOIl10 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of IL10 proteinPMID:22060784
Il10increases expressionISOIl10 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of IL10 mRNAPMID:11717450 PMID:15973123 PMID:17375199 PMID:21829567 PMID:25307695
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD[cholan-2,3,24-tryl-2,3,24-trisulfate co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 protein; [rifaximin co-treated with Trinitrobenzenesulfonic Acid] results in increased expression of IL10 protein; seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 mRNA]; soyasaponin Ab inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of IL10 protein]PMID:11717450 PMID:21599020 PMID:22060784
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