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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:28939
Term: N-acetyl-L-cysteine
Definition: An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID: MESH:D000111
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Methotrexate results in decreased secretion of IL10 protein]; Acetylcysteine promotes the reaction [Doxorubicin results in increased expression of IL10 mRNA]PMID:11124598 PMID:20885979
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTD[Eugenol co-treated with Acetylcysteine] inhibits the reaction [Nicotine results in decreased secretion of IL10 protein]; Acetylcysteine inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Azoxymethane results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Nicotine results in decreased expression of IL10 mRNA]PMID:20431929 PMID:21237301 PMID:37598416
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Acetylcysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased secretion of IL10 protein]PMID:21424515 PMID:26138014 PMID:32620109
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