RGD Reference Report - Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis. - Rat Genome Database

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Anti-inflammatory Effect of Triterpenoic Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf on Rat Model of Chronic Bronchitis.

Authors: Ge, JF  Wang, TY  Zhao, B  Lv, XW  Jin, Y  Peng, L  Yu, SC  Li, J 
Citation: Ge JF, etal., Am J Chin Med. 2009;37(2):309-21.
RGD ID: 2308951
Pubmed: PMID:19507274   (View Abstract at PubMed)
DOI: DOI:10.1142/S0192415X09006862   (Journal Full-text)

This study was designed to investigate the anti-inflammatory effect of Triterpenoic Acids from Eriobotrya japonica (Thunb.) Lindl. (TAL) on chronic bronchitis (CB) in rats. CB model was established by combination of Bacillus Calmette-Guerin (BCG, 5 mg/kg, injected through the caudal vein) and lipopolysaccharide (LPS, 1 g/L, injected through endotracheal intubation). Rats with CB model were treated with TAL (50, 150 and 450 mg/kg) for 3 weeks. The leukocytes in bronchoalveolar lavage fluid (BALF) were counted after Wright staining, the levels of cytokine tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, and IL-10 in the supernatants of lung homogenate were assessed by enzyme-linked immunosorbent assay (ELISA), and the protein expression of nuclear factor kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) on bronchial epithelium were tested by immunohistochemical staining. As compared to the normal and sham groups, the total number of leukocyte, the differential counts of neutrophils and alveolar macrophage (AM) in BALF, the levels of TNF-alpha and IL-8 in the supernatants of lung homogenate, and the expression of NF-kappaB and ICAM-1 on bronchial epithelium in CB rats were significantly increased, while the level of IL-10 was decreased. TAL (50, 150 and 450 mg/kg) attenuated these alterations in model CB rats, which indicates that TAL has anti-inflammatory effect in the rats with CB.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Chronic Bronchitis  ISOIcam1 (Rattus norvegicus)2308951; 2308951protein:increased expression:bronchial epithelium (rat)RGD 
Chronic Bronchitis  ISOIl10 (Rattus norvegicus)2308951; 2308951protein:decreased expression:lungRGD 
Chronic Bronchitis  IEP 2308951protein:increased expression:bronchial epithelium (rat)RGD 
Chronic Bronchitis  IEP 2308951protein:decreased expression:lungRGD 

Objects Annotated

Genes (Rattus norvegicus)
Icam1  (intercellular adhesion molecule 1)
Il10  (interleukin 10)

Genes (Mus musculus)
Icam1  (intercellular adhesion molecule 1)
Il10  (interleukin 10)

Genes (Homo sapiens)
ICAM1  (intercellular adhesion molecule 1)
IL10  (interleukin 10)


Additional Information