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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2886
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il10
Name: interleukin 10
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il10decreases abundanceISOIl10 (Mus musculus)6480464CTDIL10 protein results in decreased abundance of DinoprostonePMID:14975940
Il10decreases expressionISOIL10 (Homo sapiens)6480464CTDDinoprostone results in decreased expression of IL10; Dinoprostone results in decreased expression of IL10 proteinPMID:16303787 PMID:19273625
Il10increases abundanceISOIL10 (Homo sapiens)6480464CTDIL10 protein results in increased abundance of DinoprostonePMID:12548226
Il10multiple interactionsISOIl10 (Mus musculus)6480464CTDDinoprostone promotes the reaction [Zymosan results in increased expression of IL10 mRNA]; Dinoprostone promotes the reaction [Zymosan results in increased expression of IL10 protein]; IL10 gene mutant form promotes the reaction [Silicon Dioxide results in increased abundance of Dinoprostone]PMID:11301049 PMID:14975940
Il10multiple interactionsISOIL10 (Homo sapiens)6480464CTDDinoprostone inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]; IL10 protein inhibits the reaction [Endotoxins results in increased abundance of Dinoprostone]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprostone]PMID:12548226 PMID:19273625 PMID:7582491
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