GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il10 | decreases expression | EXP | | 6480464 | CTD | Cadmium results in decreased expression of IL10 mRNA | PMID:25808797 PMID:36278208 | Il10 | multiple interactions | EXP | | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 protein; Silymarin inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 protein] | PMID:36718047 | Il10 | decreases expression | ISO | Il10 (Mus musculus) | 6480464 | CTD | Cadmium results in decreased expression of IL10 protein | PMID:37357614 | Il10 | decreases secretion | ISO | IL10 (Homo sapiens) | 6480464 | CTD | Cadmium results in decreased secretion of IL10 protein | PMID:36094808 | Il10 | multiple interactions | ISO | Il10 (Mus musculus) | 6480464 | CTD | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of IL10 mRNA; [Cadmium co-treated with 2,2',4,4'-tetrabromodiphenyl ether] results in decreased expression of IL10 protein | PMID:32917723 PMID:33359024 PMID:37357614 | Il10 | multiple interactions | ISO | IL10 (Homo sapiens) | 6480464 | CTD | [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in decreased expression of IL10 mRNA; [Cadmium analog co-treated with Selenium analog co-treated with zinc sulfide analog] results in increased expression of IL10 mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA; Cadmium results in increased expression of and results in increased secretion of IL10 protein; MitoTEMPO inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA]; PPARG protein inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of IL10 mRNA] | PMID:18082304 PMID:21481475 PMID:32917723 PMID:35301059 | | ||||||||||||||||||||||
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