GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Il10 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL10 mRNA | PMID:19520675 PMID:33387578 | Il10 | affects expression | ISO | Il10 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of IL10 mRNA | PMID:21570461 | Il10 | decreases expression | ISO | Il10 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in decreased expression of IL10 mRNA; Tetrachlorodibenzodioxin results in decreased expression of IL10 protein | PMID:17681673 PMID:23999131 | Il10 | increases expression | ISO | Il10 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL10 mRNA; Tetrachlorodibenzodioxin results in increased expression of IL10 protein | PMID:12167310 PMID:18684927 PMID:20044593 PMID:20728533 PMID:21925233 PMID:22262711 PMID:26862745 | Il10 | increases expression | ISO | IL10 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of IL10 mRNA | PMID:20044593 | Il10 | multiple interactions | ISO | Il10 (Mus musculus) | 6480464 | CTD | [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the expression of IL10 mRNA; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] affects the reaction [[Dietary Sucrose co-treated with Dietary Fats] affects the expression of IL10 mRNA]; AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of IL10 mRNA]; AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; Pentachlorophenol affects the reaction [Tetrachlorodibenzodioxin inhibits the reaction [OVAL protein results in increased secretion of IL10 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [[CpG ODN 1826 binds to and results in increased activity of TLR9 protein] which results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [OVAL protein results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased expression of IL10 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Plant Extracts results in increased secretion of IL10 protein]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]; Tetrachlorodibenzodioxin results in increased expression of and results in increased secretion of IL10 protein | PMID:17681673 PMID:21097750 PMID:21804081 PMID:22262711 PMID:22491429 PMID:23999131 PMID:24051191 PMID:27562557 PMID:30722647 | Il10 | multiple interactions | ISO | IL10 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of AKT1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK1 protein]; Tetrachlorodibenzodioxin inhibits the reaction [[CD40LG protein co-treated with IL2 protein co-treated with IL6 protein co-treated with IL10 protein] affects the activity of MAPK3 protein] | PMID:21807014 | | ||||||||||||||||||||||
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