RGD Reference Report - Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study. - Rat Genome Database

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Interleukin-10 promoter polymorphism and venous thrombosis: a case-control study.

Authors: Cochery-Nouvellon, E  Vitry, F  Cornillet-Lefebvre, P  Hezard, N  Gillot, L  Nguyen, P 
Citation: Cochery-Nouvellon E, etal., Thromb Haemost. 2006 Jul;96(1):24-8.
RGD ID: 1598472
Pubmed: PMID:16807647   (View Abstract at PubMed)
DOI: DOI:10.1160/TH06-01-0027   (Journal Full-text)

The human interleukin-10 promoter gene is highly polymorphic. IL-10 polymorphisms have been associated with various autoimmune and lymphoproliferative disorders. Although IL-10 has been shown to modulate thrombin generation in several experimental models, it is not known whether IL-10 polymorphisms could be a risk factor for venous thrombosis. We therefore conducted a case-control study comparing 74 consecutive patients who experienced at least one episode of documented venous thromboembolic event and 100 healthy controls. All subjects were Caucasians. Five polymorphisms of the IL-10 promoter gene were studied: two highly polymorphic dinucleotide repeats, IL-10 R and IL-10G, and three single nucleotide polymorphisms at position -1082, -819 and -592. Factor VG1691C Leiden mutation was systematically determined. Multivariate logistic regression analysis showed that IL-10 G13 and G10 alleles are independent risk factors for venous thrombosis (Odds ratio:OR = 3.33, p = 0.003 and OR = 2.83, p = 0.03, respectively). Furthermore, IL-10 G10 allele is more frequent in recurrent disease.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Venous Thrombosis susceptibilityIAGP 1598472 RGD 
Venous Thrombosis susceptibilityISOIL10 (Homo sapiens)1598472; 1598472 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information